Analysis of a urinary biomarker panel for obstructive nephropathy and clinical outcomes

To follow up renal function changes in patients with obstructive nephropathy and to evaluate the predictive value of biomarker panel in renal prognosis. A total of 108 patients with obstructive nephropathy were enrolled in the study; 90 patients completed the follow-up. At multiple time points befor...

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Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e112865-e112865
Main Authors: Xie, Yuanyuan, Xue, Wei, Shao, Xinghua, Che, Xiajing, Xu, Weijia, Ni, Zhaohui, Mou, Shan
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - urine
Adult
Aged
Bioindicators
Biology and Life Sciences
Biomarkers
Biomarkers - urine
Creatinine
Creatinine - blood
Enzyme-linked immunosorbent assay
Enzymes
Fatty acid-binding protein
Fatty Acid-Binding Proteins - urine
Fatty acids
Female
Follow-Up Studies
Gelatinase
Glomerular Filtration Rate
Heart surgery
Hepatitis A Virus Cellular Receptor 1
Hospitals
Humans
Kidney diseases
Kidney Diseases - etiology
Kidney Diseases - urine
Kidney Function Tests
Lipocalin
Lipocalin-2
Lipocalins - urine
Liver
Male
Medical prognosis
Medicine
Medicine and Health Sciences
Membrane Glycoproteins - urine
Middle Aged
Nephrology
Nephropathy
Neutrophils
Patient Outcome Assessment
Patient outcomes
Patients
Predictions
Prognosis
Protein binding
Proteins
Proto-Oncogene Proteins - urine
Receptors, Virus
Regression analysis
Renal function
Risk analysis
Risk Factors
ROC Curve
Systematic review
Ureteral Obstruction - complications
Ureteral Obstruction - surgery
Urine
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Summary:To follow up renal function changes in patients with obstructive nephropathy and to evaluate the predictive value of biomarker panel in renal prognosis. A total of 108 patients with obstructive nephropathy were enrolled in the study; 90 patients completed the follow-up. At multiple time points before and after obstruction resolution, urinary samples were prospectively collected in patients with obstructive nephropathy; the levels of urinary kidney injury molecule-1 (uKIM-1), liver-type fatty acid-binding protein (uL-FABP), and neutrophil gelatinase associated lipocalin (uNGAL) were determined by enzyme-linked immunosorbent assay (ELISA). After 1 year of follow-up, the predictive values of biomarker panel for determining the prognosis of obstructive nephropathy were evaluated. uKIM-1 (r = 0.823), uL-FABP (r = 0.670), and uNGAL (r = 0.720) levels were positively correlated with the serum creatinine level (all P154.62 ng/mg Cr, and a 72-h postoperative uL-FABP>99.86 ng/mg Cr were all positively correlated with poor prognosis (all P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0112865