Short association fibres of the insula-temporoparietal junction in early psychosis: a diffusion tensor imaging study

• Published in: PloS one 2014-11, Vol.9 (11), p.e112842-e112842
• Main Authors: Hatton, Sean N, Lagopoulos, Jim, Hermens, Daniel F, Hickie, Ian B, Scott, Elizabeth, Bennett, Maxwell R
• Format: Article
• Language: English
• Subjects: Abnormalities; Adolescent; Adult; Age; Age of Onset; Aging; Anatomy; Anisotropy; Asymmetry; Biology and Life Sciences; Brain; Brain research; Cerebral Cortex - pathology; Cortex; Diffusion Tensor Imaging; Fibers; Hallucinations; Humans; Magnetic resonance; Magnetic Resonance Imaging; Masks; Medical imaging; Medicine and Health Sciences; Mental disorders; Nerve Fibers, Unmyelinated - pathology; Neuropathology; Psychosis; Psychotic Disorders - pathology; Schizophrenia; Seeding; Substantia alba; Substantia grisea; Temporal gyrus; Temporomandibular Joint - pathology; Young adults
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0112842

Evidence shows that there are reductions in gray matter volume (GMV) and changes in long association white matter fibres within the left insula-temporoparietal junction (TPJ) during the early stages of psychotic disorders but less is known about short association fibres (sAFs). In this study we sought to characterise the changes in sAFs and associated volumetric changes of the left insula-TPJ during the early stages of psychosis. Magnetic resonance imaging was obtained from a sample of young people with psychosis (n = 42) and healthy controls (n = 45), and cortical parcellations of the left insula-TPJ were used as seeding masks to reconstruct 13 sAFs. Compared to healthy counterparts, the psychosis group showed significant reductions in fractional anisotropy (FA) in the sAFs connecting the superior (STG) and middle temporal gyri (MTG) and as well as reduced GMV within the inferior temporal gyrus and increased white matter volume (WMV) within Heschl's gyrus (HG). Furthermore, adolescent-onset psychosis subjects (onset 18 year or earlier) showed FA reductions in the STG-HG sAF when compared to adult-onset subjects, but this was not associated with changes in GMV nor WMV of the STG or HG. These findings suggest that during the early stages of psychosis, changes in sAFs and associated cortical GMV and WMV appear to occur independently, however age of onset of a psychotic syndrome/disorder influences the pattern of neuroanatomical abnormalities.