Survey of phytochemical composition and biological effects of three extracts from a wild plant (Cotoneaster nummularia Fisch. et Mey.): a potential source for functional food ingredients and drug formulations

• Published in: PloS one 2014-11, Vol.9 (11), p.e113527
• Main Authors: Zengin, Gokhan, Uysal, Ahmet, Gunes, Erdogan, Aktumsek, Abdurrahman
• Format: Article
• Language: English
• Subjects: Acetates - chemistry; Acids; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antimutagenic Agents - chemistry; Antimutagenic Agents - isolation & purification; Antimutagenic Agents - pharmacology; Antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Biological effects; Biology and Life Sciences; Carcinogens; Chelation; Chemistry, Pharmaceutical; Chlorogenic acid; Cholinesterase; Chromatography, High Pressure Liquid; Colorimetry; Composition effects; Cotoneaster nummularia; Diabetes; Drug resistance; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - metabolism; Enzymes; Enzymes - chemistry; Enzymes - metabolism; Epicatechin; Ferulic acid; Flavonoids; Flavonoids - analysis; Flavonoids - chemistry; Flavonoids - pharmacology; Food plants; Food sources; Formulations; Functional Food; Functional foods & nutraceuticals; Gram-Negative Bacteria - drug effects; Gram-Negative Bacteria - isolation & purification; Gram-Positive Bacteria - drug effects; Gram-Positive Bacteria - isolation & purification; Herbal medicine; High-performance liquid chromatography; Humans; Linoleic acid; Liquid chromatography; Medicine and Health Sciences; Metabolism; Metabolites; Methanol - chemistry; Microbial Sensitivity Tests; Mutagenicity Tests; Natural products; Pharmaceuticals; Phenolic compounds; Phenols; Phenols - analysis; Phenols - chemistry; Phenols - pharmacology; Phytochemicals; Plant extracts; Plant Extracts - chemistry; Plant Extracts - pharmacology; Protein Binding; Rosaceae - chemistry; Rosaceae - metabolism; Salmonella typhimurium - drug effects; Salmonella typhimurium - genetics; Studies; Tyrosinase; Water - chemistry; β-Carotene
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0113527

This study was focused on the analysis of the phenolic content, antioxidant, antibacterial, anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase activity of three solvent extracts from Cotoneaster nummularia. Moreover, water extract was tested in terms of mutagenic/anti-mutagenic effects. The antioxidant activities of these extracts were evaluated by DPPH, ABTS, O2, metal chelating, phosphomolybdenum, β-carotene/linoleic acid, ferric and cupric reducing power assays. Enzyme inhibitory activities were also examined with colorimetric methods. Generally, methanol and water extracts exhibited excellent biological activities. These extracts were rich in phenolic and flavonoid content. Furthermore, Cotoneaster extracts indicated appreciable antibacterial properties against human pathogen strains. HPLC analysis showed that ferulic acid, chlorogenic acid, (-) - epicatechin and (+)-catechin were the major phenolics in extracts tested. These data offer that these extracts from C. nummularia may be considered as a potential source of biological agents for developing functional foods or drug formulations.