Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study

Chronic gastro-duodenal reflux in the esophagus is a major risk for intestinal metaplasia and Barrett's adenocarcinoma. A role for chronic use of proton pump inhibitor (PPI) in the increased incidence of esophageal adenocarcinoma in Western countries has been previously suggested. The aim of th...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e112862
Main Authors: Dall'Olmo, Luigi, Fassan, Matteo, Dassie, Elisa, Scarpa, Marco, Realdon, Stefano, Cavallin, Francesco, Cagol, Matteo, Battaglia, Giorgio, Pizzi, Marco, Guzzardo, Vincenza, Franceschinis, Erica, Pasut, Gianfranco, Rugge, Massimo, Zaninotto, Giovanni, Realdon, Nicola, Castoro, Carlo
Format: Article
Language:English
Subjects:
Acids
Adenocarcinoma
Analgesics
Animals
Biology and Life Sciences
Cancer
Carcinogenesis
Carcinogens
Cell Transformation, Neoplastic
Drug dosages
Endoscopy
Epithelium
Esophageal cancer
Esophageal Neoplasms - pathology
Esophagus
Gastroenterology
Health aspects
In vivo methods and tests
Incidence
Inhibitors
Intestine
Invasiveness
Laboratories
Lesions
Male
Medicine
Medicine and Health Sciences
Metaplasia
Mortality
Multilayers
Omeprazole
Oncology
Pancreas
Pancreas - pathology
Pathology
Pharmaceuticals
Pharmacology
Proton pump inhibitors
Proton Pump Inhibitors - pharmacology
Protons
Randomization
Rats
Rats, Sprague-Dawley
Research and Analysis Methods
Rodents
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c758t-f2d3c0d385e67fc3a3ce7db3c39dc6cbec12f6b5e5522a3a68b6ee1cb61e2f33
cites cdi_FETCH-LOGICAL-c758t-f2d3c0d385e67fc3a3ce7db3c39dc6cbec12f6b5e5522a3a68b6ee1cb61e2f33
container_end_page
container_issue 11
container_start_page e112862
container_title PloS one
container_volume 9
creator Dall'Olmo, Luigi
Fassan, Matteo
Dassie, Elisa
Scarpa, Marco
Realdon, Stefano
Cavallin, Francesco
Cagol, Matteo
Battaglia, Giorgio
Pizzi, Marco
Guzzardo, Vincenza
Franceschinis, Erica
Pasut, Gianfranco
Rugge, Massimo
Zaninotto, Giovanni
Realdon, Nicola
Castoro, Carlo
description Chronic gastro-duodenal reflux in the esophagus is a major risk for intestinal metaplasia and Barrett's adenocarcinoma. A role for chronic use of proton pump inhibitor (PPI) in the increased incidence of esophageal adenocarcinoma in Western countries has been previously suggested. The aim of this work was to study the effect of chronic administration of omeprazole (a proton pump inhibitor) per os in a model of reflux induced esophageal carcinogenesis. One week after esophago-gastro-jejunostomy, 115 Sprague-Dawley rats were randomized to receive 10 mg/Kg per day of omeprazole or placebo, 5 days per week. The esophago-gastric specimens were collected 28 ± 2 weeks after randomization and analyzed in a blinded fashion. Mortality and esophageal metaplasia rates did not differ between the two groups (p = 0.99 for mortality, p = 0.36 for intestinal metaplasia and p = 0.66 for multi-layered epithelium). Gastric pancreatic acinar cell metaplasia (PACM) was more frequently observed in PPI-treated rats (p = 0.003). Severe ulcer lesions significantly prevailed in the placebo group (p = 0.03). Locally invasive esophageal epithelial neoplasia were observed in 23/39 PPI-treated versus 14/42 placebo-animals (p = 0.03). In conclusion, chronic omeprazole treatment improved the healing of esophageal ulcerative lesions. Locally invasive neoplastic lesions and PACM prevailed among PPI-treated animals. However, neither an effect on the overall mortality nor on the incidence of pre-neoplastic lesions was observed in this work.
doi_str_mv 10.1371/journal.pone.0112862
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1626822583</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A418139014</galeid><doaj_id>oai_doaj_org_article_f891580958834c3ca7dfc022e093f5fd</doaj_id><sourcerecordid>A418139014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-f2d3c0d385e67fc3a3ce7db3c39dc6cbec12f6b5e5522a3a68b6ee1cb61e2f33</originalsourceid><addsrcrecordid>eNqNk9tq3DAQhk1padK0b1BaQaHQi93qYGntXBRC6GEhEEhDb4Usj7xabMmV7CV5hr50tV0nrKGFogtLo-__PRpmsuw1wUvCVuTj1o_BqXbZewdLTAgtBH2SnZKS0YWgmD092p9kL2LcYsxZIcTz7ITynHBS4tPs141vAXmD-uAH71A_dj2ybmMrO_iAUgSi7zeqAdUirYK2zjfgINqIlKtRr5wOoAarkUp3KiANbYs6GFTfqmgVqmEHre87cMN5kiC46yHY_TE5Wod2dudRHMb6_mX2zKg2wqvpe5bdfvl8e_ltcXX9dX15cbXQK14MC0NrpnHNCg5iZTRTTMOqrphmZa2FrkATakTFgXNKFVOiqAQA0ZUgQA1jZ9nbg23f-iinMkZJBBUFpbzYE-sDUXu1lX3KVoV76ZWVfwI-NFKF9OQWpClKwgtc8qJguWZarWqjMaWAS2a4qZPXp-lvY9VBrdO7g2pnpvMbZzey8TuZ0xzzlUgG7yaD4H-OEId_pDxRjUpZWWd8MtOdjVpe5KQgrMQkT9TyL1RaNXRWp0YyNsVngg8zQWIGuBsaNcYo199v_p-9_jFn3x-xm9Rcwyb6dhysd3EO5gdQBx9jAPNYOYLlfg4eqiH3cyCnOUiyN8dVfxQ9ND77DR8MBs8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1626822583</pqid></control><display><type>article</type><title>Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study</title><source>PMC (PubMed Central)</source><source>Publicly Available Content (ProQuest)</source><creator>Dall'Olmo, Luigi ; Fassan, Matteo ; Dassie, Elisa ; Scarpa, Marco ; Realdon, Stefano ; Cavallin, Francesco ; Cagol, Matteo ; Battaglia, Giorgio ; Pizzi, Marco ; Guzzardo, Vincenza ; Franceschinis, Erica ; Pasut, Gianfranco ; Rugge, Massimo ; Zaninotto, Giovanni ; Realdon, Nicola ; Castoro, Carlo</creator><contributor>Mukaisho, Ken-ichi</contributor><creatorcontrib>Dall'Olmo, Luigi ; Fassan, Matteo ; Dassie, Elisa ; Scarpa, Marco ; Realdon, Stefano ; Cavallin, Francesco ; Cagol, Matteo ; Battaglia, Giorgio ; Pizzi, Marco ; Guzzardo, Vincenza ; Franceschinis, Erica ; Pasut, Gianfranco ; Rugge, Massimo ; Zaninotto, Giovanni ; Realdon, Nicola ; Castoro, Carlo ; Mukaisho, Ken-ichi</creatorcontrib><description>Chronic gastro-duodenal reflux in the esophagus is a major risk for intestinal metaplasia and Barrett's adenocarcinoma. A role for chronic use of proton pump inhibitor (PPI) in the increased incidence of esophageal adenocarcinoma in Western countries has been previously suggested. The aim of this work was to study the effect of chronic administration of omeprazole (a proton pump inhibitor) per os in a model of reflux induced esophageal carcinogenesis. One week after esophago-gastro-jejunostomy, 115 Sprague-Dawley rats were randomized to receive 10 mg/Kg per day of omeprazole or placebo, 5 days per week. The esophago-gastric specimens were collected 28 ± 2 weeks after randomization and analyzed in a blinded fashion. Mortality and esophageal metaplasia rates did not differ between the two groups (p = 0.99 for mortality, p = 0.36 for intestinal metaplasia and p = 0.66 for multi-layered epithelium). Gastric pancreatic acinar cell metaplasia (PACM) was more frequently observed in PPI-treated rats (p = 0.003). Severe ulcer lesions significantly prevailed in the placebo group (p = 0.03). Locally invasive esophageal epithelial neoplasia were observed in 23/39 PPI-treated versus 14/42 placebo-animals (p = 0.03). In conclusion, chronic omeprazole treatment improved the healing of esophageal ulcerative lesions. Locally invasive neoplastic lesions and PACM prevailed among PPI-treated animals. However, neither an effect on the overall mortality nor on the incidence of pre-neoplastic lesions was observed in this work.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0112862</identifier><identifier>PMID: 25415190</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Adenocarcinoma ; Analgesics ; Animals ; Biology and Life Sciences ; Cancer ; Carcinogenesis ; Carcinogens ; Cell Transformation, Neoplastic ; Drug dosages ; Endoscopy ; Epithelium ; Esophageal cancer ; Esophageal Neoplasms - pathology ; Esophagus ; Gastroenterology ; Health aspects ; In vivo methods and tests ; Incidence ; Inhibitors ; Intestine ; Invasiveness ; Laboratories ; Lesions ; Male ; Medicine ; Medicine and Health Sciences ; Metaplasia ; Mortality ; Multilayers ; Omeprazole ; Oncology ; Pancreas ; Pancreas - pathology ; Pathology ; Pharmaceuticals ; Pharmacology ; Proton pump inhibitors ; Proton Pump Inhibitors - pharmacology ; Protons ; Randomization ; Rats ; Rats, Sprague-Dawley ; Research and Analysis Methods ; Rodents ; Surgery</subject><ispartof>PloS one, 2014-11, Vol.9 (11), p.e112862</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Dall'Olmo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Dall'Olmo et al 2014 Dall'Olmo et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-f2d3c0d385e67fc3a3ce7db3c39dc6cbec12f6b5e5522a3a68b6ee1cb61e2f33</citedby><cites>FETCH-LOGICAL-c758t-f2d3c0d385e67fc3a3ce7db3c39dc6cbec12f6b5e5522a3a68b6ee1cb61e2f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1626822583/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1626822583?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25415190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mukaisho, Ken-ichi</contributor><creatorcontrib>Dall'Olmo, Luigi</creatorcontrib><creatorcontrib>Fassan, Matteo</creatorcontrib><creatorcontrib>Dassie, Elisa</creatorcontrib><creatorcontrib>Scarpa, Marco</creatorcontrib><creatorcontrib>Realdon, Stefano</creatorcontrib><creatorcontrib>Cavallin, Francesco</creatorcontrib><creatorcontrib>Cagol, Matteo</creatorcontrib><creatorcontrib>Battaglia, Giorgio</creatorcontrib><creatorcontrib>Pizzi, Marco</creatorcontrib><creatorcontrib>Guzzardo, Vincenza</creatorcontrib><creatorcontrib>Franceschinis, Erica</creatorcontrib><creatorcontrib>Pasut, Gianfranco</creatorcontrib><creatorcontrib>Rugge, Massimo</creatorcontrib><creatorcontrib>Zaninotto, Giovanni</creatorcontrib><creatorcontrib>Realdon, Nicola</creatorcontrib><creatorcontrib>Castoro, Carlo</creatorcontrib><title>Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chronic gastro-duodenal reflux in the esophagus is a major risk for intestinal metaplasia and Barrett's adenocarcinoma. A role for chronic use of proton pump inhibitor (PPI) in the increased incidence of esophageal adenocarcinoma in Western countries has been previously suggested. The aim of this work was to study the effect of chronic administration of omeprazole (a proton pump inhibitor) per os in a model of reflux induced esophageal carcinogenesis. One week after esophago-gastro-jejunostomy, 115 Sprague-Dawley rats were randomized to receive 10 mg/Kg per day of omeprazole or placebo, 5 days per week. The esophago-gastric specimens were collected 28 ± 2 weeks after randomization and analyzed in a blinded fashion. Mortality and esophageal metaplasia rates did not differ between the two groups (p = 0.99 for mortality, p = 0.36 for intestinal metaplasia and p = 0.66 for multi-layered epithelium). Gastric pancreatic acinar cell metaplasia (PACM) was more frequently observed in PPI-treated rats (p = 0.003). Severe ulcer lesions significantly prevailed in the placebo group (p = 0.03). Locally invasive esophageal epithelial neoplasia were observed in 23/39 PPI-treated versus 14/42 placebo-animals (p = 0.03). In conclusion, chronic omeprazole treatment improved the healing of esophageal ulcerative lesions. Locally invasive neoplastic lesions and PACM prevailed among PPI-treated animals. However, neither an effect on the overall mortality nor on the incidence of pre-neoplastic lesions was observed in this work.</description><subject>Acids</subject><subject>Adenocarcinoma</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cell Transformation, Neoplastic</subject><subject>Drug dosages</subject><subject>Endoscopy</subject><subject>Epithelium</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Gastroenterology</subject><subject>Health aspects</subject><subject>In vivo methods and tests</subject><subject>Incidence</subject><subject>Inhibitors</subject><subject>Intestine</subject><subject>Invasiveness</subject><subject>Laboratories</subject><subject>Lesions</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metaplasia</subject><subject>Mortality</subject><subject>Multilayers</subject><subject>Omeprazole</subject><subject>Oncology</subject><subject>Pancreas</subject><subject>Pancreas - pathology</subject><subject>Pathology</subject><subject>Pharmaceuticals</subject><subject>Pharmacology</subject><subject>Proton pump inhibitors</subject><subject>Proton Pump Inhibitors - pharmacology</subject><subject>Protons</subject><subject>Randomization</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><subject>Surgery</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1BaQaHQi93qYGntXBRC6GEhEEhDb4Usj7xabMmV7CV5hr50tV0nrKGFogtLo-__PRpmsuw1wUvCVuTj1o_BqXbZewdLTAgtBH2SnZKS0YWgmD092p9kL2LcYsxZIcTz7ITynHBS4tPs141vAXmD-uAH71A_dj2ybmMrO_iAUgSi7zeqAdUirYK2zjfgINqIlKtRr5wOoAarkUp3KiANbYs6GFTfqmgVqmEHre87cMN5kiC46yHY_TE5Wod2dudRHMb6_mX2zKg2wqvpe5bdfvl8e_ltcXX9dX15cbXQK14MC0NrpnHNCg5iZTRTTMOqrphmZa2FrkATakTFgXNKFVOiqAQA0ZUgQA1jZ9nbg23f-iinMkZJBBUFpbzYE-sDUXu1lX3KVoV76ZWVfwI-NFKF9OQWpClKwgtc8qJguWZarWqjMaWAS2a4qZPXp-lvY9VBrdO7g2pnpvMbZzey8TuZ0xzzlUgG7yaD4H-OEId_pDxRjUpZWWd8MtOdjVpe5KQgrMQkT9TyL1RaNXRWp0YyNsVngg8zQWIGuBsaNcYo199v_p-9_jFn3x-xm9Rcwyb6dhysd3EO5gdQBx9jAPNYOYLlfg4eqiH3cyCnOUiyN8dVfxQ9ND77DR8MBs8</recordid><startdate>20141121</startdate><enddate>20141121</enddate><creator>Dall'Olmo, Luigi</creator><creator>Fassan, Matteo</creator><creator>Dassie, Elisa</creator><creator>Scarpa, Marco</creator><creator>Realdon, Stefano</creator><creator>Cavallin, Francesco</creator><creator>Cagol, Matteo</creator><creator>Battaglia, Giorgio</creator><creator>Pizzi, Marco</creator><creator>Guzzardo, Vincenza</creator><creator>Franceschinis, Erica</creator><creator>Pasut, Gianfranco</creator><creator>Rugge, Massimo</creator><creator>Zaninotto, Giovanni</creator><creator>Realdon, Nicola</creator><creator>Castoro, Carlo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141121</creationdate><title>Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study</title><author>Dall'Olmo, Luigi ; Fassan, Matteo ; Dassie, Elisa ; Scarpa, Marco ; Realdon, Stefano ; Cavallin, Francesco ; Cagol, Matteo ; Battaglia, Giorgio ; Pizzi, Marco ; Guzzardo, Vincenza ; Franceschinis, Erica ; Pasut, Gianfranco ; Rugge, Massimo ; Zaninotto, Giovanni ; Realdon, Nicola ; Castoro, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-f2d3c0d385e67fc3a3ce7db3c39dc6cbec12f6b5e5522a3a68b6ee1cb61e2f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acids</topic><topic>Adenocarcinoma</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Cell Transformation, Neoplastic</topic><topic>Drug dosages</topic><topic>Endoscopy</topic><topic>Epithelium</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagus</topic><topic>Gastroenterology</topic><topic>Health aspects</topic><topic>In vivo methods and tests</topic><topic>Incidence</topic><topic>Inhibitors</topic><topic>Intestine</topic><topic>Invasiveness</topic><topic>Laboratories</topic><topic>Lesions</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metaplasia</topic><topic>Mortality</topic><topic>Multilayers</topic><topic>Omeprazole</topic><topic>Oncology</topic><topic>Pancreas</topic><topic>Pancreas - pathology</topic><topic>Pathology</topic><topic>Pharmaceuticals</topic><topic>Pharmacology</topic><topic>Proton pump inhibitors</topic><topic>Proton Pump Inhibitors - pharmacology</topic><topic>Protons</topic><topic>Randomization</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Research and Analysis Methods</topic><topic>Rodents</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dall'Olmo, Luigi</creatorcontrib><creatorcontrib>Fassan, Matteo</creatorcontrib><creatorcontrib>Dassie, Elisa</creatorcontrib><creatorcontrib>Scarpa, Marco</creatorcontrib><creatorcontrib>Realdon, Stefano</creatorcontrib><creatorcontrib>Cavallin, Francesco</creatorcontrib><creatorcontrib>Cagol, Matteo</creatorcontrib><creatorcontrib>Battaglia, Giorgio</creatorcontrib><creatorcontrib>Pizzi, Marco</creatorcontrib><creatorcontrib>Guzzardo, Vincenza</creatorcontrib><creatorcontrib>Franceschinis, Erica</creatorcontrib><creatorcontrib>Pasut, Gianfranco</creatorcontrib><creatorcontrib>Rugge, Massimo</creatorcontrib><creatorcontrib>Zaninotto, Giovanni</creatorcontrib><creatorcontrib>Realdon, Nicola</creatorcontrib><creatorcontrib>Castoro, Carlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dall'Olmo, Luigi</au><au>Fassan, Matteo</au><au>Dassie, Elisa</au><au>Scarpa, Marco</au><au>Realdon, Stefano</au><au>Cavallin, Francesco</au><au>Cagol, Matteo</au><au>Battaglia, Giorgio</au><au>Pizzi, Marco</au><au>Guzzardo, Vincenza</au><au>Franceschinis, Erica</au><au>Pasut, Gianfranco</au><au>Rugge, Massimo</au><au>Zaninotto, Giovanni</au><au>Realdon, Nicola</au><au>Castoro, Carlo</au><au>Mukaisho, Ken-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-21</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e112862</spage><pages>e112862-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chronic gastro-duodenal reflux in the esophagus is a major risk for intestinal metaplasia and Barrett's adenocarcinoma. A role for chronic use of proton pump inhibitor (PPI) in the increased incidence of esophageal adenocarcinoma in Western countries has been previously suggested. The aim of this work was to study the effect of chronic administration of omeprazole (a proton pump inhibitor) per os in a model of reflux induced esophageal carcinogenesis. One week after esophago-gastro-jejunostomy, 115 Sprague-Dawley rats were randomized to receive 10 mg/Kg per day of omeprazole or placebo, 5 days per week. The esophago-gastric specimens were collected 28 ± 2 weeks after randomization and analyzed in a blinded fashion. Mortality and esophageal metaplasia rates did not differ between the two groups (p = 0.99 for mortality, p = 0.36 for intestinal metaplasia and p = 0.66 for multi-layered epithelium). Gastric pancreatic acinar cell metaplasia (PACM) was more frequently observed in PPI-treated rats (p = 0.003). Severe ulcer lesions significantly prevailed in the placebo group (p = 0.03). Locally invasive esophageal epithelial neoplasia were observed in 23/39 PPI-treated versus 14/42 placebo-animals (p = 0.03). In conclusion, chronic omeprazole treatment improved the healing of esophageal ulcerative lesions. Locally invasive neoplastic lesions and PACM prevailed among PPI-treated animals. However, neither an effect on the overall mortality nor on the incidence of pre-neoplastic lesions was observed in this work.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25415190</pmid><doi>10.1371/journal.pone.0112862</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2014-11, Vol.9 (11), p.e112862
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1626822583
source PMC (PubMed Central); Publicly Available Content (ProQuest)
subjects Acids
Adenocarcinoma
Analgesics
Animals
Biology and Life Sciences
Cancer
Carcinogenesis
Carcinogens
Cell Transformation, Neoplastic
Drug dosages
Endoscopy
Epithelium
Esophageal cancer
Esophageal Neoplasms - pathology
Esophagus
Gastroenterology
Health aspects
In vivo methods and tests
Incidence
Inhibitors
Intestine
Invasiveness
Laboratories
Lesions
Male
Medicine
Medicine and Health Sciences
Metaplasia
Mortality
Multilayers
Omeprazole
Oncology
Pancreas
Pancreas - pathology
Pathology
Pharmaceuticals
Pharmacology
Proton pump inhibitors
Proton Pump Inhibitors - pharmacology
Protons
Randomization
Rats
Rats, Sprague-Dawley
Research and Analysis Methods
Rodents
Surgery
title Role of proton pump inhibitor on esophageal carcinogenesis and pancreatic acinar cell metaplasia development: an experimental in vivo study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T00%3A49%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20proton%20pump%20inhibitor%20on%20esophageal%20carcinogenesis%20and%20pancreatic%20acinar%20cell%20metaplasia%20development:%20an%20experimental%20in%20vivo%20study&rft.jtitle=PloS%20one&rft.au=Dall'Olmo,%20Luigi&rft.date=2014-11-21&rft.volume=9&rft.issue=11&rft.spage=e112862&rft.pages=e112862-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0112862&rft_dat=%3Cgale_plos_%3EA418139014%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c758t-f2d3c0d385e67fc3a3ce7db3c39dc6cbec12f6b5e5522a3a68b6ee1cb61e2f33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1626822583&rft_id=info:pmid/25415190&rft_galeid=A418139014&rfr_iscdi=true