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Comparison of the effects of transarterial chemoembolization for advanced hepatocellular carcinoma between patients with and without extrahepatic metastases

Sorafenib is a standard treatment for advanced hepatocellular carcinoma (HCC) (Barcelona Clinic Liver Cancer [BCLC] stage C). However, transarterial chemoembolization (TACE) has also been widely used as a treatment for patients with advanced HCC, even if they have extrahepatic metastases (EHM). The...

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Published in:PloS one 2014-11, Vol.9 (11), p.e113926-e113926
Main Authors: Yoo, Jeong-Ju, Lee, Jeong-Hoon, Lee, Sang Hwan, Lee, Minjong, Lee, Dong Hyeon, Cho, Yuri, Lee, Yun Bin, Yu, Su Jong, Kim, Hyo-Cheol, Kim, Yoon Jun, Yoon, Jung-Hwan, Kim, Chung Yong, Lee, Hyo-Suk
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Language:English
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Summary:Sorafenib is a standard treatment for advanced hepatocellular carcinoma (HCC) (Barcelona Clinic Liver Cancer [BCLC] stage C). However, transarterial chemoembolization (TACE) has also been widely used as a treatment for patients with advanced HCC, even if they have extrahepatic metastases (EHM). The aim of this study was to determine the efficacy of TACE for advanced HCC patients with EHM upon initial diagnosis, as compared with those patients without EHM. This cohort study involved consecutive patients who underwent TACE as an initial treatment for advanced HCC. One hundred seventy-seven patients with EHM (the EHM group) and 205 with portal vein invasion without EHM (the non-EHM group) were included. A survival analysis was performed to compare overall survival between the two groups. The mean age was 54.5±9.9 years, and median follow-up duration was 13.1 months (range, 0.5-111.0). Overall survival was significantly shorter in the EHM group than the non-EHM group (median, 8.3 vs. 19.1 months; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0113926