Leukotriene production is increased in abdominal obesity

Obesity is a major risk factor for insulin resistance and type-2 diabetes. A chronic low grade inflammatory state has been described during obesity and associated with insulin resistance pathogenesis. Results from animal studies are in favor of a role of the leukotriene (LT) pathway in obesity induc...

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Bibliographic Details
Published in:PloS one 2014-12, Vol.9 (12), p.e104593-e104593
Main Authors: Bäck, Magnus, Avignon, Antoine, Stanke-Labesque, Françoise, Boegner, Catherine, Attalin, Vincent, Leprieur, Elodie, Sultan, Ariane
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Apnea
Biology and Life Sciences
Blood pressure
Body mass
Body mass index
C-Reactive Protein - metabolism
Cohort Studies
Diabetes mellitus
Female
Females
Glucose tolerance
Hip
Humans
Immunological tolerance
Insulin
Insulin Resistance
Leukotrienes - biosynthesis
Leukotrienes - urine
Male
Medicin och hälsovetenskap
Medicine and Health Sciences
Middle Aged
Multivariate Analysis
Nutrition
Obesity
Obesity, Abdominal - complications
Obesity, Abdominal - metabolism
Obesity, Abdominal - urine
Research and Analysis Methods
Risk factors
Sleep
Sleep apnea
Sleep Apnea Syndromes - complications
Sleep Apnea Syndromes - metabolism
Sleep disorders
Young Adult
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Summary:Obesity is a major risk factor for insulin resistance and type-2 diabetes. A chronic low grade inflammatory state has been described during obesity and associated with insulin resistance pathogenesis. Results from animal studies are in favor of a role of the leukotriene (LT) pathway in obesity induced-insulin resistance. However, there is a paucity of data regarding this association in human obesity. Therefore, the aim of this study was to investigate whether LT production was associated with insulin resistance and other metabolic parameters in a cohort of obese subjects. Forty-six (70% females) obese subjects (BMI≧30 kg/m2) without known diabetes and without inflammatory disease (CRP
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0104593