Different plasma markers of inflammation are influenced by immune recovery and cART composition or intensification in treated HIV infected individuals

HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART with raltegravir reduced CD8 T-cell activation in the Discor-Ral and IntegRal studies, we have evaluated th...

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Bibliographic Details
Published in:PloS one 2014-12, Vol.9 (12), p.e114142-e114142
Main Authors: Massanella, Marta, Ouchi, Dan, Marfil, Silvia, Llibre, Josep M, Puertas, Maria C, Buzón, María J, Richman, Douglas D, Orna, Elisa, Stevenson, Mario, Gatell, Josep M, Domingo, Pere, Negredo, Eugènia, Martinez-Picado, Javier, Clotet, Bonaventura, Blanco, Julià
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Amplification
Analysis
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiretrovirals
Biochemical markers
Biology and Life Sciences
Biomarkers - blood
CD4 antigen
CD8 antigen
Cell activation
Coagulation
Composition
Dimers
Female
Health aspects
Hepatitis C virus
Highly active antiretroviral therapy
HIV
HIV infections
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - immunology
HIV Integrase Inhibitors - administration & dosage
HIV Integrase Inhibitors - therapeutic use
HIV patients
Human immunodeficiency virus
Humans
Infeccions per VIH
Infection
Infections
Inflamació
Inflammation
Inflammation - blood
Integrals
Lymphocytes
Lymphocytes T
Male
Marcadors bioquímics
Markers
Medicine and health sciences
Middle Aged
Patients
Plasma levels
Prospective Studies
Protease inhibitors
Proteases
Proteinase inhibitors
Raltegravir Potassium - administration & dosage
Raltegravir Potassium - therapeutic use
Recovery (Medical)
Replication
T cell receptors
T cells
Virus replication
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Description
Summary:HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART with raltegravir reduced CD8 T-cell activation in the Discor-Ral and IntegRal studies, we have evaluated the effect of raltegravir intensification on several soluble inflammation markers in these studies. Longitudinal plasma samples (0-48 weeks) from the IntegRal (n = 67, 22 control and 45 intensified individuals) and the Discor-Ral studies (44 individuals with CD4 T-cell counts
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0114142