Randomised trial of text messaging on adherence to cardiovascular preventive treatment (INTERACT trial)

About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease pre...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-12, Vol.9 (12), p.e114268-e114268
Main Authors: Wald, David S, Bestwick, Jonathan P, Raiman, Lewis, Brendell, Rebecca, Wald, Nicholas J
Format: Article
Language:English
Subjects:
Adhesion
Aged
Analysis
Anticholesteremic agents
Blood
Blood pressure
Blood Pressure - drug effects
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - psychology
Cardiovascular System - drug effects
Cell Phone
Cellular telephones
Clinical trials
Coronary artery disease
Coronary heart disease
Data processing
Disease prevention
Drugs
Female
Heart diseases
Humans
Lipid Metabolism - drug effects
Lipids
Malaria
Male
Medical treatment
Medication Adherence
Medicine and Health Sciences
Middle Aged
Patient compliance
Patients
Prevention
Preventive medicine
Primary care
Randomization
Short message service
Side effects
Stroke
Text Messaging
Texts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:About one third of patients prescribed blood pressure or lipid-lowering drugs for the prevention of coronary heart disease and stroke do not take their medication as prescribed. We conducted a randomized trial to evaluate text messaging as a means of improving adherence to cardiovascular disease preventive treatment. 303 patients taking blood pressure and/or lipid-lowering medications were randomly assigned to being sent text messages (Text group, 151) or not being sent them (No text group, 152). Texts were sent daily for 2 weeks, alternate days for 2 weeks and weekly thereafter for 22 weeks (6 months overall), using an automated computer programme. Patients were asked to respond on whether they had taken their medication, whether the text reminded them to do so if they had forgotten, and if they had not taken their medication to determine if there was a reason for not doing so. At 6 months, use of medication was assessed. Two patients were lost to follow-up, providing data on 301 for analysis. In the No text group 38/151 (25%) took less than 80% of the prescribed regimen (ie. stopped medication completely or took it on fewer than 22 of the last 28 days of follow-up) compared to 14/150 patients (9%) in the Text group - an improvement in adherence affecting 16 per 100 patients (95% CI 7 to 24), p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0114268