Graft-versus-host disease prophylaxis after transplantation: a network meta-analysis

Graft-versus-host Disease (GvHD) prophylaxis after allogeneic hematopoietic stem-cell transplantation (HSCT) is an ongoing effort but relative effects of different policies are not systematically explored. We systematically reviewed 30-year evidence on GvHD prophylaxis and quantified the relative ef...

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Bibliographic Details
Published in:PloS one 2014-12, Vol.9 (12), p.e114735-e114735
Main Authors: Ziakas, Panayiotis D, Zervou, Fainareti N, Zacharioudakis, Ioannis M, Mylonakis, Eleftherios
Format: Article
Language:English
Subjects:
Analysis
Antilymphocyte Serum - therapeutic use
Clinical trials
Conditioning
Corticoids
Corticosteroids
Cyclosporin A
Globulins
Graft versus host disease
Graft vs Host Disease - etiology
Graft vs Host Disease - prevention & control
Graft-versus-host reaction
Hematologic Diseases - therapy
Hematopoietic stem cell transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Immunosuppressive agents
Meta-analysis
Methotrexate
Mycophenolate mofetil
Mycophenolic acid
Policies
Prophylaxis
Randomization
Randomized Controlled Trials as Topic
Rapamycin
Stem cell transplantation
Stem cells
Tacrolimus
Thymocytes
Transplantation
Transplants
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Summary:Graft-versus-host Disease (GvHD) prophylaxis after allogeneic hematopoietic stem-cell transplantation (HSCT) is an ongoing effort but relative effects of different policies are not systematically explored. We systematically reviewed 30-year evidence on GvHD prophylaxis and quantified the relative effect of different policies using a network meta-analysis. We searched PubMed and the Cochrane Library for randomized studies on the topic. The primary outcome of interest was grade II-IV acute GvHD over 0 or I (with odds ratio OR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0114735