Metabolism of skin-absorbed resveratrol into its glucuronized form in mouse skin

Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribu...

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Bibliographic Details
Published in:PloS one 2014-12, Vol.9 (12), p.e115359-e115359
Main Authors: Murakami, Itsuo, Chaleckis, Romanas, Pluskal, Tomáš, Ito, Ken, Hori, Kousuke, Ebe, Masahiro, Yanagida, Mitsuhiro, Kondoh, Hiroshi
Format: Article
Language:English
Subjects:
Absorption
Administration, Cutaneous
Aging
Animals
Bioavailability
Biological Availability
Biology and Life Sciences
Cancer
Cell cycle
Cells, Cultured
Chemicals
Diabetes
Ethanol
Experiments
Female
Frailty
Geriatrics
Glucuronides - metabolism
Hospitals
Humans
Inflammation - drug therapy
Kinases
Laboratory animals
Laboratory tests
Liver
Male
Medicine and Health Sciences
Metabolism
Metabolites
Metabolomics
Mice
Oral administration
Pharmacology
Physical Sciences
Plant tissues
Research and Analysis Methods
Research methodology
Resveratrol
Rodents
Sarcopenia
Skin
Skin - metabolism
Skin Absorption
Stilbenes - administration & dosage
Stilbenes - metabolism
Stilbenes - pharmacokinetics
Stilbenes - therapeutic use
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Summary:Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability. This study compared RESV metabolites and their tissue distribution after oral uptake and skin absorption. Metabolomic analysis of various mouse tissues revealed that RESV can be absorbed and metabolized through skin. We detected sulfated and glucuronidated RESV metabolites, as well as dihydroresveratrol. These metabolites are thought to have lower pharmacological activity than RESV. Similar quantities of most RESV metabolites were observed 4 h after oral or skin administration, except that glucuronidated RESV metabolites were more abundant in skin after topical RESV application than after oral administration. This result is consistent with our finding of glucuronidated RESV metabolites in cultured skin cells. RESV applied to mouse ears significantly suppressed inflammation in the TPA inflammation model. The skin absorption route could be a complementary, potent way to achieve therapeutic effects with RESV.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0115359