First-in-human trial of a novel suprachoroidal retinal prosthesis

Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical app...

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Bibliographic Details
Published in:PloS one 2014-12, Vol.9 (12), p.e115239-e115239
Main Authors: Ayton, Lauren N, Blamey, Peter J, Guymer, Robyn H, Luu, Chi D, Nayagam, David A X, Sinclair, Nicholas C, Shivdasani, Mohit N, Yeoh, Jonathan, McCombe, Mark F, Briggs, Robert J, Opie, Nicholas L, Villalobos, Joel, Dimitrov, Peter N, Varsamidis, Mary, Petoe, Matthew A, McCarthy, Chris D, Walker, Janine G, Barnes, Nick, Burkitt, Anthony N, Williams, Chris E, Shepherd, Robert K, Allen, Penelope J
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Bionics
Choroid - surgery
Consortia
Electrodes
Engineering and Technology
Eye (anatomy)
FDA approval
Female
Hospitals
Humans
Male
Medical research
Medicine and Health Sciences
Mental health
Middle Aged
Neural prostheses
Ophthalmologic Surgical Procedures - instrumentation
Ophthalmologic Surgical Procedures - methods
Patients
Postoperative Complications
Prostheses
Prostheses and implants
Prosthetics
Restoration
Retina
Retinitis
Retinitis pigmentosa
Retinitis Pigmentosa - surgery
Safety
Sclera - surgery
Surgery
Surgical implants
Transplants & implants
Vision
Visual Prosthesis - adverse effects
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Summary:Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration. Clinicaltrials.gov NCT01603576.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0115239