Gene electro transfer of plasmid encoding vascular endothelial growth factor for enhanced expression and perfusion in the ischemic swine heart

Myocardial ischemia can damage heart muscle and reduce the heart's pumping efficiency. This study used an ischemic swine heart model to investigate the potential for gene electro transfer of a plasmid encoding vascular endothelial growth factor for improving perfusion and, thus, for reducing ca...

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Bibliographic Details
Published in:PloS one 2014-12, Vol.9 (12), p.e115235-e115235
Main Authors: Hargrave, Barbara, Strange, Jr, Robert, Navare, Sagar, Stratton, Michael, Burcus, Nina, Murray, Len, Lundberg, Cathryn, Bulysheva, Anna, Li, Fanying, Heller, Richard
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Biology and Life Sciences
Calcium-binding protein
Cardiac muscle
Cardiac output
Cardiomyopathy
Comparative analysis
Coronary vessels
Creatine
Creatine kinase
Deoxyribonucleic acid
DNA
Echocardiography
Electrocardiography
Electrodes
Electroporation - methods
Engineering and Technology
Feasibility studies
Gene expression
Gene therapy
Genes
Genetic Therapy - methods
Genetic Vectors - genetics
Health sciences
Heart
Heart attacks
Heart diseases
Heart failure
Ischemia
Laboratory animals
Livestock
Medicine and Health Sciences
Muscles
Musculoskeletal system
Myocardial ischemia
Myocardial Ischemia - therapy
Perfusion
Pulse duration
Research and Analysis Methods
Risk management
Statistical analysis
Stroke
Stroke volume
Swine
Troponin
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
Veins & arteries
Ventricle
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Summary:Myocardial ischemia can damage heart muscle and reduce the heart's pumping efficiency. This study used an ischemic swine heart model to investigate the potential for gene electro transfer of a plasmid encoding vascular endothelial growth factor for improving perfusion and, thus, for reducing cardiomyopathy following acute coronary syndrome. Plasmid expression was significantly greater in gene electro transfer treated tissue compared to injection of plasmid encoding vascular endothelial growth factor alone. Higher gene expression was also seen in ischemic versus non-ischemic groups with parameters 20 Volts (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0115235