The diagnostic value of clinical symptoms in women and men presenting with chest pain at the emergency department, a prospective cohort study

Previous studies suggested that diagnosing coronary artery disease (CAD) is more difficult in women than in men. Studies investigating the predictive value of clinical signs and symptoms and compare its combined diagnostic value between women and men are lacking. Data from a large multicenter prospe...

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Bibliographic Details
Published in:PloS one 2015-01, Vol.10 (1), p.e0116431-e0116431
Main Authors: van der Meer, Manon G, Backus, Barbra E, van der Graaf, Yolanda, Cramer, Maarten J, Appelman, Yolande, Doevendans, Pieter A, Six, A Jacob, Nathoe, Hendrik M
Format: Article
Language:English
Subjects:
Adult
Aged
Angiography
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - diagnosis
Chest
Chest pain
Chest Pain - diagnosis
Chest Pain - etiology
Cohort analysis
Coronary artery
Coronary artery disease
Coronary Artery Disease - complications
Coronary Artery Disease - diagnosis
Diagnosis
Diagnostic imaging
Diagnostic systems
Electrocardiography
Emergency medical services
Emergency Service, Hospital
Female
Gender differences
Health risk assessment
Health risks
Heart attack
Heart diseases
Hospital emergency services
Humans
Male
Medical diagnosis
Men
Middle Aged
Myocardial infarction
Pain
Patients
Predictive Value of Tests
Prospective Studies
Risk analysis
Risk Assessment
Risk Factors
Signs and symptoms
Stenosis
Symptom Assessment
Women
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Summary:Previous studies suggested that diagnosing coronary artery disease (CAD) is more difficult in women than in men. Studies investigating the predictive value of clinical signs and symptoms and compare its combined diagnostic value between women and men are lacking. Data from a large multicenter prospective study was used. Patients admitted to the emergency department (ED) with chest pain but without ST-elevation were eligible. The endpoint was proven CAD, defined as a significant stenosis at angiography or the diagnosis of a non-ST-elevation myocardial infarction or cardiovascular death within six weeks after presentation at the ED. Twelve clinical symptoms and seven cardiovascular risk factors were collected. Potential predictors of CAD with a p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0116431