Carotid intima-media thickness at age 30, birth weight, accelerated growth during infancy and breastfeeding: a birth cohort study in Southern Brazil

To examine the relationship between carotid intima-media thickness (IMT) at age 30 and birth characteristics, growth during infancy, and breastfeeding duration, among subjects who have been prospectively followed since birth. In 1982, all births in the city of Pelotas, southern Brazil, were identifi...

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Bibliographic Details
Published in:PloS one 2015-01, Vol.10 (1), p.e0115166-e0115166
Main Authors: Linhares, Rogério da Silva, Gigante, Denise Petrucci, de Barros, Fernando Celso Lopes Fernandes, Horta, Bernardo Lessa
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Arteries
Atherosclerosis
Birth Weight
Blood pressure
Body measurements
Brazil
Breast Feeding
Breastfeeding & lactation
Carotid arteries
Carotid Arteries - anatomy & histology
Carotid Arteries - growth & development
Carotid artery
Child Development
Child, Preschool
Children
Children & youth
Coefficients
Cohort analysis
Cohort Studies
Disease
Epidemiology
Families & family life
Female
Heart attacks
Heat affected zone
Humans
Infant, Newborn
Low income groups
Male
Maternal & child health
Planes
Studies
Tunica Intima - anatomy & histology
Tunica Intima - growth & development
Ultrasonic imaging
Ultrasound
Ultrasound imaging
Urban areas
Veins & arteries
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Summary:To examine the relationship between carotid intima-media thickness (IMT) at age 30 and birth characteristics, growth during infancy, and breastfeeding duration, among subjects who have been prospectively followed since birth. In 1982, all births in the city of Pelotas, southern Brazil, were identified and those children (n = 5,914) whose families lived in the urban area of the city have been followed and evaluated at several time points. The cohort participants were evaluated in 2012-13, and IMT was measured at the posterior wall of the right and left common carotid arteries in longitudinal planes using ultrasound imaging. We obtained valid IMT measurements for 3,188 individuals. Weight-for-age z-score (WAZ) at age 2 years, weight-for-height z-score (WHZ) at age 4, height-for-age z-score (HAZ) at 4 years, WAZ at age 4 and relative conditional weight at 4 years were positively associated with IMT, even after controlling for confounding variables. The beta-coefficient associated with ≥ 1 s.d. WAZ at age 2 (compared to those with a
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0115166