Gender differences in in-hospital clinical outcomes after percutaneous coronary interventions: an insight from a Japanese multicenter registry

Gender differences in clinical outcomes after percutaneous coronary intervention (PCI) among different age groups are controversial in the era of drug-eluting stents, especially among the Asian population who are at higher risk for bleeding complications. We analyzed data from 10,220 patients who un...

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Published in:PloS one 2015-01, Vol.10 (1), p.e0116496-e0116496
Main Authors: Numasawa, Yohei, Kohsaka, Shun, Miyata, Hiroaki, Noma, Shigetaka, Suzuki, Masahiro, Ishikawa, Shiro, Nakamura, Iwao, Nishi, Yutaro, Ohki, Takahiro, Negishi, Koji, Takahashi, Toshiyuki, Fukuda, Keiichi
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age
Aged
Aged, 80 and over
Angioplasty
Balloon angioplasty
Bifurcations
Bleeding
Body mass
Body mass index
Body size
Cardiac patients
Cardiology
Cardiovascular disease
Clinical outcomes
Complications
Coronary Artery Disease - epidemiology
Coronary Artery Disease - surgery
Data processing
Diabetes mellitus
Drug delivery
Drug dosages
Female
Gender
Gender aspects
Gender differences
Heart attacks
Heart diseases
Heart failure
Hospitals
Humans
Hyperlipidemia
Hypertension
Implants
Insulin
Intervention
Japan
Kidneys
Lesions
Male
Men
Middle Aged
Mortality
Multivariate Analysis
Patient outcomes
Patients
Percutaneous Coronary Intervention - adverse effects
Postoperative Complications - epidemiology
Registries
Renal failure
Risk Factors
Sex differences
Sex Distribution
Stents
Studies
Surgical implants
Treatment Outcome
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cited_by cdi_FETCH-LOGICAL-c758t-5bcc3c3d57cf9e528de9f36b502b47f503b16fe552fd3a77ee84c8f4f48c68473
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creator Numasawa, Yohei
Kohsaka, Shun
Miyata, Hiroaki
Noma, Shigetaka
Suzuki, Masahiro
Ishikawa, Shiro
Nakamura, Iwao
Nishi, Yutaro
Ohki, Takahiro
Negishi, Koji
Takahashi, Toshiyuki
Fukuda, Keiichi
description Gender differences in clinical outcomes after percutaneous coronary intervention (PCI) among different age groups are controversial in the era of drug-eluting stents, especially among the Asian population who are at higher risk for bleeding complications. We analyzed data from 10,220 patients who underwent PCI procedures performed at 14 Japanese hospitals from September 2008 to April 2013. A total of 2,106 (20.6%) patients were women. Women were older (72.7±9.7 vs 66.6±10.8 years, p
doi_str_mv 10.1371/journal.pone.0116496
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We analyzed data from 10,220 patients who underwent PCI procedures performed at 14 Japanese hospitals from September 2008 to April 2013. A total of 2,106 (20.6%) patients were women. Women were older (72.7±9.7 vs 66.6±10.8 years, p<0.001), and had a lower body mass index (23.4±4.0 vs 24.3±3.5, p<0.001), with a higher prevalence of hypertension (p<0.001), hyperlipidemia (p<0.001), insulin-dependent diabetes (p<0.001), renal failure (p<0.001), and heart failure (p<0.001) compared with men. Men tended to have more bifurcation lesions (p = 0.003) and chronic totally occluded lesions (p<0.001) than women. Crude overall complications (14.8% vs 9.5%, p<0.001) and the rate of bleeding complications (5.3% vs 2.8%, p<0.001) were significantly higher in women than in men. On multivariate analysis in the total cohort, female sex was an independent predictor of overall complications (OR, 1.47; 95% CI, 1.26-1.71; p<0.001) and bleeding complications (OR, 1.74; 95% CI, 1.36-2.24; p<0.001) after adjustment for confounding variables. A similar trend was observed across the middle-aged group (≥55 and <75 years) and old age group (≥75 years). 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Women are at higher risk than men for post-procedural complications after PCI, regardless of age.]]></description><subject>Acute coronary syndromes</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angioplasty</subject><subject>Balloon angioplasty</subject><subject>Bifurcations</subject><subject>Bleeding</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cardiac patients</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Clinical outcomes</subject><subject>Complications</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - surgery</subject><subject>Data processing</subject><subject>Diabetes mellitus</subject><subject>Drug delivery</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Gender</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Implants</subject><subject>Insulin</subject><subject>Intervention</subject><subject>Japan</subject><subject>Kidneys</subject><subject>Lesions</subject><subject>Male</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Percutaneous Coronary Intervention - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Numasawa, Yohei</au><au>Kohsaka, Shun</au><au>Miyata, Hiroaki</au><au>Noma, Shigetaka</au><au>Suzuki, Masahiro</au><au>Ishikawa, Shiro</au><au>Nakamura, Iwao</au><au>Nishi, Yutaro</au><au>Ohki, Takahiro</au><au>Negishi, Koji</au><au>Takahashi, Toshiyuki</au><au>Fukuda, Keiichi</au><au>Moretti, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender differences in in-hospital clinical outcomes after percutaneous coronary interventions: an insight from a Japanese multicenter registry</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-01-30</date><risdate>2015</risdate><volume>10</volume><issue>1</issue><spage>e0116496</spage><epage>e0116496</epage><pages>e0116496-e0116496</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[Gender differences in clinical outcomes after percutaneous coronary intervention (PCI) among different age groups are controversial in the era of drug-eluting stents, especially among the Asian population who are at higher risk for bleeding complications. We analyzed data from 10,220 patients who underwent PCI procedures performed at 14 Japanese hospitals from September 2008 to April 2013. A total of 2,106 (20.6%) patients were women. Women were older (72.7±9.7 vs 66.6±10.8 years, p<0.001), and had a lower body mass index (23.4±4.0 vs 24.3±3.5, p<0.001), with a higher prevalence of hypertension (p<0.001), hyperlipidemia (p<0.001), insulin-dependent diabetes (p<0.001), renal failure (p<0.001), and heart failure (p<0.001) compared with men. Men tended to have more bifurcation lesions (p = 0.003) and chronic totally occluded lesions (p<0.001) than women. Crude overall complications (14.8% vs 9.5%, p<0.001) and the rate of bleeding complications (5.3% vs 2.8%, p<0.001) were significantly higher in women than in men. On multivariate analysis in the total cohort, female sex was an independent predictor of overall complications (OR, 1.47; 95% CI, 1.26-1.71; p<0.001) and bleeding complications (OR, 1.74; 95% CI, 1.36-2.24; p<0.001) after adjustment for confounding variables. A similar trend was observed across the middle-aged group (≥55 and <75 years) and old age group (≥75 years). Women are at higher risk than men for post-procedural complications after PCI, regardless of age.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25635905</pmid><doi>10.1371/journal.pone.0116496</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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issn 1932-6203
1932-6203
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source Publicly Available Content Database; PubMed Central
subjects Acute coronary syndromes
Age
Aged
Aged, 80 and over
Angioplasty
Balloon angioplasty
Bifurcations
Bleeding
Body mass
Body mass index
Body size
Cardiac patients
Cardiology
Cardiovascular disease
Clinical outcomes
Complications
Coronary Artery Disease - epidemiology
Coronary Artery Disease - surgery
Data processing
Diabetes mellitus
Drug delivery
Drug dosages
Female
Gender
Gender aspects
Gender differences
Heart attacks
Heart diseases
Heart failure
Hospitals
Humans
Hyperlipidemia
Hypertension
Implants
Insulin
Intervention
Japan
Kidneys
Lesions
Male
Men
Middle Aged
Mortality
Multivariate Analysis
Patient outcomes
Patients
Percutaneous Coronary Intervention - adverse effects
Postoperative Complications - epidemiology
Registries
Renal failure
Risk Factors
Sex differences
Sex Distribution
Stents
Studies
Surgical implants
Treatment Outcome
title Gender differences in in-hospital clinical outcomes after percutaneous coronary interventions: an insight from a Japanese multicenter registry
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