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Cost-effectiveness analysis of brief and expanded evidence-based risk reduction interventions for HIV-infected people who inject drugs in the United States

Two behavioral HIV prevention interventions for people who inject drugs (PWID) infected with HIV include the Holistic Health Recovery Program for HIV+ (HHRP+), a comprehensive evidence-based CDC-supported program, and an abbreviated Holistic Health for HIV (3H+) Program, an adapted HHRP+ version in...

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Published in:PloS one 2015-02, Vol.10 (2), p.e0116694
Main Authors: Song, Dahye L, Altice, Frederick L, Copenhaver, Michael M, Long, Elisa F
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Altice, Frederick L
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Long, Elisa F
description Two behavioral HIV prevention interventions for people who inject drugs (PWID) infected with HIV include the Holistic Health Recovery Program for HIV+ (HHRP+), a comprehensive evidence-based CDC-supported program, and an abbreviated Holistic Health for HIV (3H+) Program, an adapted HHRP+ version in treatment settings. We compared the projected health benefits and cost-effectiveness of both programs, in addition to opioid substitution therapy (OST), to the status quo in the U.S. A dynamic HIV transmission model calibrated to epidemic data of current US populations was created. Projected outcomes include future HIV incidence, HIV prevalence, and quality-adjusted life years (QALYs) gained under alternative strategies. Total medical costs were estimated to compare the cost-effectiveness of each strategy. Over 10 years, expanding HHRP+ access to 80% of PWID could avert up to 29,000 HIV infections, or 6% of the projected total, at a cost of $7,777/QALY gained. Alternatively, 3H+ could avert 19,000 infections, but is slightly more cost-effective ($7,707/QALY), and remains so under widely varying effectiveness and cost assumptions. Nearly two-thirds of infections averted with either program are among non-PWIDs, due to reduced sexual transmission from PWID to their partners. Expanding these programs with broader OST coverage could avert up to 74,000 HIV infections over 10 years and reduce HIV prevalence from 16.5% to 14.1%, but is substantially more expensive than HHRP+ or 3H+ alone. Both behavioral interventions were effective and cost-effective at reducing HIV incidence among both PWID and the general adult population; however, 3H+, the economical HHRP+ version, was slightly more cost-effective than HHRP+.
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Expanding these programs with broader OST coverage could avert up to 74,000 HIV infections over 10 years and reduce HIV prevalence from 16.5% to 14.1%, but is substantially more expensive than HHRP+ or 3H+ alone. Both behavioral interventions were effective and cost-effective at reducing HIV incidence among both PWID and the general adult population; however, 3H+, the economical HHRP+ version, was slightly more cost-effective than HHRP+.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25658949</pmid><doi>10.1371/journal.pone.0116694</doi><tpages>e0116694</tpages><oa>free_for_read</oa></addata></record>
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subjects Acquired immune deficiency syndrome
Adolescent
Adult
AIDS
Antiretroviral drugs
Behavior modification
Clinical decision making
Clinical trials
Cost analysis
Cost benefit analysis
Costs and Cost Analysis
Decision making
Disease prevention
Disease transmission
Drug abuse
Drugs
Economic aspects
Economic conditions
Epidemics
Female
GDP
Gross Domestic Product
Health insurance
Health risks
Health surveillance
HIV
HIV infections
HIV Infections - complications
HIV Infections - economics
HIV Infections - epidemiology
HIV-1
Human behavior
Human immunodeficiency virus
Humans
Incidence
Infections
Intervention
Male
Medical economics
Middle Aged
Mortality
Opioids
Patients
Prevalence
Prevention
Prevention programs
Public health
Retrospective Studies
Risk factors
Risk reduction
Sexual behavior
Sexual transmission
Sexually transmitted diseases
STD
Substance-Related Disorders - complications
Substance-Related Disorders - economics
Substance-Related Disorders - epidemiology
Systematic review
United States - epidemiology
title Cost-effectiveness analysis of brief and expanded evidence-based risk reduction interventions for HIV-infected people who inject drugs in the United States
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