Plasma amino acid profiling identifies specific amino acid associations with cardiovascular function in patients with systolic heart failure

The heart has close interactions with other organs' functions and concomitant systemic factors such as oxidative stress, nitric oxide (NO), inflammation, and nutrition in systolic heart failure (HF). Recently, plasma amino acid (AA) profiling as a systemic metabolic indicator has attracted cons...

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Bibliographic Details
Published in:PloS one 2015-02, Vol.10 (2), p.e0117325-e0117325
Main Authors: Hakuno, Daihiko, Hamba, Yasuhito, Toya, Takumi, Adachi, Takeshi
Format: Article
Language:English
Subjects:
Acids
Adult
Aged
Aged, 80 and over
Albumin
Amino acids
Amino Acids - blood
Analysis
Biomarkers
Brain natriuretic peptide
C-reactive protein
Cardiac patients
Cardiology
Cardiovascular disease
Cardiovascular system
Care and treatment
Case-Control Studies
Chromatography
Coronary vessels
Correlation
Diabetes
Echocardiography
Enzymes
Ethanolamines
Factor analysis
Female
Geriatrics
Health risks
Heart
Heart diseases
Heart failure
Heart Failure, Systolic - blood
Heart Failure, Systolic - metabolism
High performance liquid chromatography
Histidine
Hospitals
Humans
Inflow
Internal medicine
Liquid chromatography
Liver
Male
Medical prognosis
Medicine
Metabolism
Metabolites
Methionine
Middle Aged
Monoethanolamine (MEA)
Muscles
Musculoskeletal system
Natriuretic peptides
Nitrates
Nitric oxide
Nutrition
Organs
Oxidative stress
Pathogenesis
Patients
Proteins
Pulmonary arteries
Researchers
Serum albumin
Skeletal muscle
Spectrum analysis
Studies
Tyrosine
Ventricle
Young Adult
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Description
Summary:The heart has close interactions with other organs' functions and concomitant systemic factors such as oxidative stress, nitric oxide (NO), inflammation, and nutrition in systolic heart failure (HF). Recently, plasma amino acid (AA) profiling as a systemic metabolic indicator has attracted considerable attention in predicting the future risk of human cardiometabolic diseases, but it has been scarcely studied in HF. Thirty-eight stable but greater than New York Heart Association class II symptomatic patients with left ventricular (LV) ejection fraction
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0117325