Assessment of the concentrations of various advanced glycation end-products in beverages and foods that are commonly consumed in Japan

Dietary consumption has recently been identified as a major environmental source of pro-inflammatory advanced glycation end-products (AGEs) in humans. It is disputed whether dietary AGEs represent a risk to human health. Nε-(carboxymethyl)lysine (CML), a representative AGE compound found in food, ha...

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Published in:PloS one 2015-03, Vol.10 (3), p.e0118652-e0118652
Main Authors: Takeuchi, Masayoshi, Takino, Jun-Ichi, Furuno, Satomi, Shirai, Hikari, Kawakami, Mihoko, Muramatsu, Michiru, Kobayashi, Yuka, Yamagishi, Sho-Ichi
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Age
Amino acids
Antibodies
Antibodies - immunology
Arteriosclerosis
Atherosclerosis
Atherosclerosis - etiology
Bacteria
Beverages
Beverages - analysis
Biomarkers
Biomarkers - analysis
Cakes
Carbonates
Carbonation
Carboxymethyllysine
Cereals
Chromatography
Chronic illnesses
Confectionery
Diabetes
Diet
Dietary intake
Enzyme-Linked Immunosorbent Assay
Food
Food Analysis
Fructose
Fruit juices
Fruits
Gene expression
Glucose
Glycation End Products, Advanced - blood
Glycation End Products, Advanced - immunology
Glycation End Products, Advanced - metabolism
Glyceraldehyde
Glycosylation
Health aspects
Health risks
Hemoglobin
Hemoglobins
Humans
Immunoassays
Inflammation
Japan
Laboratories
Lactic acid
Lactic acid bacteria
Lysine
Lysine - analogs & derivatives
Lysine - analysis
Mass spectrometry
Oxidative stress
Pathogenesis
Pharmaceutical sciences
Prepared foods
Proteins
Rats
Risk Factors
Rodents
Scientific imaging
Serum levels
Snack foods
Studies
Sugar
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cited_by cdi_FETCH-LOGICAL-c692t-552b8ce7b4200595c17ea19c444b12808c2f2a3cbbafa6bb4a5fcc86d02870253
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creator Takeuchi, Masayoshi
Takino, Jun-Ichi
Furuno, Satomi
Shirai, Hikari
Kawakami, Mihoko
Muramatsu, Michiru
Kobayashi, Yuka
Yamagishi, Sho-Ichi
description Dietary consumption has recently been identified as a major environmental source of pro-inflammatory advanced glycation end-products (AGEs) in humans. It is disputed whether dietary AGEs represent a risk to human health. Nε-(carboxymethyl)lysine (CML), a representative AGE compound found in food, has been suggested to make a significant contribution to circulating CML levels. However, recent studies have found that the dietary intake of AGEs is not associated with plasma CML concentrations. We have shown that the serum levels of glyceraldehyde-derived AGEs (Glycer-AGEs), but not hemoglobin A1c, glucose-derived AGEs (Glu-AGEs), or CML, could be used as biomarkers for predicting the progression of atherosclerosis and future cardiovascular events. We also detected the production/accumulation of Glycer-AGEs in normal rats administered Glu-AGE-rich beverages. Therefore, we assessed the concentrations of various AGEs in a total of 1,650 beverages and foods that are commonly consumed in Japan. The concentrations of four kinds of AGEs (Glu-AGEs, fructose-derived AGEs (Fru-AGEs), CML, and Glycer-AGEs) were measured with competitive enzyme-linked immunosorbent assays involving immunoaffinity-purified specific antibodies. The results of the latter assays indicated that Glu-AGEs and Fru-AGEs (especially Glu-AGEs), but not CML or Glycer-AGEs, are present at appreciable levels in beverages and foods that are commonly consumed by Japanese. Glu-AGEs, Fru-AGEs, CML, and Glycer-AGEs exhibited concentrations of ≥85%, 2-12%,
doi_str_mv 10.1371/journal.pone.0118652
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It is disputed whether dietary AGEs represent a risk to human health. Nε-(carboxymethyl)lysine (CML), a representative AGE compound found in food, has been suggested to make a significant contribution to circulating CML levels. However, recent studies have found that the dietary intake of AGEs is not associated with plasma CML concentrations. We have shown that the serum levels of glyceraldehyde-derived AGEs (Glycer-AGEs), but not hemoglobin A1c, glucose-derived AGEs (Glu-AGEs), or CML, could be used as biomarkers for predicting the progression of atherosclerosis and future cardiovascular events. We also detected the production/accumulation of Glycer-AGEs in normal rats administered Glu-AGE-rich beverages. Therefore, we assessed the concentrations of various AGEs in a total of 1,650 beverages and foods that are commonly consumed in Japan. 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We provide useful data on the concentrations of various AGEs, especially Glu-AGEs, in commonly consumed beverages and foods.</description><subject>Advanced glycosylation end products</subject><subject>Age</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Antibodies - immunology</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - etiology</subject><subject>Bacteria</subject><subject>Beverages</subject><subject>Beverages - analysis</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Cakes</subject><subject>Carbonates</subject><subject>Carbonation</subject><subject>Carboxymethyllysine</subject><subject>Cereals</subject><subject>Chromatography</subject><subject>Chronic illnesses</subject><subject>Confectionery</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Food</subject><subject>Food Analysis</subject><subject>Fructose</subject><subject>Fruit juices</subject><subject>Fruits</subject><subject>Gene expression</subject><subject>Glucose</subject><subject>Glycation End Products, Advanced - blood</subject><subject>Glycation End Products, Advanced - immunology</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Glyceraldehyde</subject><subject>Glycosylation</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Humans</subject><subject>Immunoassays</subject><subject>Inflammation</subject><subject>Japan</subject><subject>Laboratories</subject><subject>Lactic acid</subject><subject>Lactic acid bacteria</subject><subject>Lysine</subject><subject>Lysine - analogs &amp; 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Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeuchi, Masayoshi</au><au>Takino, Jun-Ichi</au><au>Furuno, Satomi</au><au>Shirai, Hikari</au><au>Kawakami, Mihoko</au><au>Muramatsu, Michiru</au><au>Kobayashi, Yuka</au><au>Yamagishi, Sho-Ichi</au><au>Hudson, Barry I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the concentrations of various advanced glycation end-products in beverages and foods that are commonly consumed in Japan</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-02</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0118652</spage><epage>e0118652</epage><pages>e0118652-e0118652</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Dietary consumption has recently been identified as a major environmental source of pro-inflammatory advanced glycation end-products (AGEs) in humans. It is disputed whether dietary AGEs represent a risk to human health. Nε-(carboxymethyl)lysine (CML), a representative AGE compound found in food, has been suggested to make a significant contribution to circulating CML levels. However, recent studies have found that the dietary intake of AGEs is not associated with plasma CML concentrations. We have shown that the serum levels of glyceraldehyde-derived AGEs (Glycer-AGEs), but not hemoglobin A1c, glucose-derived AGEs (Glu-AGEs), or CML, could be used as biomarkers for predicting the progression of atherosclerosis and future cardiovascular events. We also detected the production/accumulation of Glycer-AGEs in normal rats administered Glu-AGE-rich beverages. Therefore, we assessed the concentrations of various AGEs in a total of 1,650 beverages and foods that are commonly consumed in Japan. The concentrations of four kinds of AGEs (Glu-AGEs, fructose-derived AGEs (Fru-AGEs), CML, and Glycer-AGEs) were measured with competitive enzyme-linked immunosorbent assays involving immunoaffinity-purified specific antibodies. The results of the latter assays indicated that Glu-AGEs and Fru-AGEs (especially Glu-AGEs), but not CML or Glycer-AGEs, are present at appreciable levels in beverages and foods that are commonly consumed by Japanese. Glu-AGEs, Fru-AGEs, CML, and Glycer-AGEs exhibited concentrations of ≥85%, 2-12%, &lt;3%, and trace amounts in the examined beverages and ≥82%, 5-15%, &lt;3%, and trace amounts in the tested foods, respectively. The results of the present study indicate that some lactic acid bacteria beverages, carbonated drinks, sugar-sweetened fruit drinks, sports drinks, mixed fruit juices, confectionery (snacks), dried fruits, cakes, cereals, and prepared foods contain markedly higher Glu-AGE levels than other classes of beverages and foods. We provide useful data on the concentrations of various AGEs, especially Glu-AGEs, in commonly consumed beverages and foods.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25730321</pmid><doi>10.1371/journal.pone.0118652</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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issn 1932-6203
1932-6203
language eng
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subjects Advanced glycosylation end products
Age
Amino acids
Antibodies
Antibodies - immunology
Arteriosclerosis
Atherosclerosis
Atherosclerosis - etiology
Bacteria
Beverages
Beverages - analysis
Biomarkers
Biomarkers - analysis
Cakes
Carbonates
Carbonation
Carboxymethyllysine
Cereals
Chromatography
Chronic illnesses
Confectionery
Diabetes
Diet
Dietary intake
Enzyme-Linked Immunosorbent Assay
Food
Food Analysis
Fructose
Fruit juices
Fruits
Gene expression
Glucose
Glycation End Products, Advanced - blood
Glycation End Products, Advanced - immunology
Glycation End Products, Advanced - metabolism
Glyceraldehyde
Glycosylation
Health aspects
Health risks
Hemoglobin
Hemoglobins
Humans
Immunoassays
Inflammation
Japan
Laboratories
Lactic acid
Lactic acid bacteria
Lysine
Lysine - analogs & derivatives
Lysine - analysis
Mass spectrometry
Oxidative stress
Pathogenesis
Pharmaceutical sciences
Prepared foods
Proteins
Rats
Risk Factors
Rodents
Scientific imaging
Serum levels
Snack foods
Studies
Sugar
title Assessment of the concentrations of various advanced glycation end-products in beverages and foods that are commonly consumed in Japan
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