In utero exposure to diethylstilbestrol and blood DNA methylation in women ages 40-59 years from the sister study

In utero exposure to diethylstilbestrol (DES) has been associated with increased risk of adverse health outcomes such as fertility problems and vaginal as well as breast cancer. Animal studies have linked prenatal DES exposure to lasting DNA methylation changes. We investigated genome-wide DNA methy...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0118757-e0118757
Main Authors: Harlid, Sophia, Xu, Zongli, Panduri, Vijayalakshmi, D'Aloisio, Aimee A, DeRoo, Lisa A, Sandler, Dale P, Taylor, Jack A
Format: Article
Language:English
Subjects:
Adult
Age
Blood
Blood cells
Breast cancer
Cancer
Cell growth
Cohort Studies
CpG Islands
Daughters
Deoxyribonucleic acid
Diethylstilbestrol
Diethylstilbestrol - adverse effects
DNA
DNA - blood
DNA - drug effects
DNA Methylation
Environmental health
Epidemiology
Epigenetics
Estrogens
Estrogens, Non-Steroidal - adverse effects
Exposure
Female
Fertility
Gene expression
Genetic aspects
Genetics
Genomes
Genomics
Health aspects
Health risks
Health sciences
Humans
Infertility
Intrauterine exposure
Laboratories
Linear Models
Methylation
Middle Aged
Miscarriage
Mothers
Pregnancy
Pregnant women
Prenatal experience
Prenatal Exposure Delayed Effects - chemically induced
Prenatal Exposure Delayed Effects - genetics
Regression analysis
Robustness (mathematics)
Siblings
Studies
Surveys and Questionnaires
Vagina
Womens health
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Summary:In utero exposure to diethylstilbestrol (DES) has been associated with increased risk of adverse health outcomes such as fertility problems and vaginal as well as breast cancer. Animal studies have linked prenatal DES exposure to lasting DNA methylation changes. We investigated genome-wide DNA methylation and in utero DES exposure in a sample of non-Hispanic white women aged 40-59 years from the Sister Study, a large United States cohort study of women with a family history of breast cancer. Using questionnaire information from women and their mothers, we selected 100 women whose mothers reported taking DES while pregnant and 100 control women whose mothers had not taken DES. DNA methylation in blood was measured at 485,577 CpG sites using the Illumina HumanMethylation450 BeadChip. Associations between CpG methylation and DES exposure status were analyzed using robust linear regression with adjustment for blood cell composition and multiple comparisons. Although four CpGs had p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0118757