Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice

Due to the absolute need for arginine that certain cancer cells have, arginine depletion is a therapy in clinical trials to treat several types of cancers. Arginine is an amino acids utilized not only as a precursor for other important molecules, but also for protein synthesis. Because arginine depl...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0119801-e0119801
Main Authors: Marini, Juan C, Didelija, Inka Cajo
Format: Article
Language:English
Subjects:
Agriculture
Amino acids
Animal tissues
Animals
Arginine
Arginine - blood
Arginine deiminase
Body composition
Body mass
Body weight
Brain
Cancer
Carbon 14
Catheters
Chemical synthesis
Citrulline
Clinical trials
Depletion
Enzymes
Feeds
Hydrolases - pharmacology
Kidneys
Laboratory animals
Large intestine
Lean body mass
Liver
Lungs
Male
Medical prognosis
Medical research
Medicine
Metabolism
Mice
Mice, Inbred ICR
Muscle Proteins - biosynthesis
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscles
Neoplasms - blood
Neoplasms - drug therapy
Nutrition research
Pancreas
Pediatrics
Physiological aspects
Polyethylene glycol
Polyethylene Glycols - pharmacology
Protein biosynthesis
Protein metabolism
Protein synthesis
Protein turnover
Proteins
Spleen
Stomach
Thymus
Veins & arteries
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Summary:Due to the absolute need for arginine that certain cancer cells have, arginine depletion is a therapy in clinical trials to treat several types of cancers. Arginine is an amino acids utilized not only as a precursor for other important molecules, but also for protein synthesis. Because arginine depletion can potentially exacerbate the progressive loss of body weight, and especially lean body mass, in cancer patients we determined the effect of arginine depletion by pegylated arginine deiminase (ADI-PEG 20) on whole body protein synthesis and fractional protein synthesis rate in multiple tissues of mice. ADI-PEG 20 successfully depleted circulating arginine (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0119801