Retinal vein occlusion and pregnancy, pre-eclampsia, and eclampsia: the results from a nationwide, population-based study using the national claim database

• Published in: PloS one 2015-03, Vol.10 (3), p.e0120067-e0120067
• Main Authors: Park, Sang Jun, Choi, Nam-Kyong, Seo, Kyung Ha, Park, Kyu Hyung, Woo, Se Joon
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Child; Childbirth & labor; Comparative analysis; Data bases; Datasets; Diabetes; Disease; Eclampsia - epidemiology; Female; Health care; Health insurance; Hospitals; Humans; Incidence; Male; Medical diagnosis; Medical research; Medicine; Occlusion; Patients; Population; Population studies; Population-based studies; Pre-eclampsia; Pre-Eclampsia - epidemiology; Preeclampsia; Pregnancy; Pregnant women; Public health; Republic of Korea; Retina; Retinal diseases; Retinal Vein Occlusion - complications; Retinal Vein Occlusion - epidemiology; Risk factors; Standardization; Thrombosis; Veins & arteries; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0120067

To investigate the incidence of retinal vein occlusion (RVO) in pregnant women and in the subpopulation of pregnant women with pre-eclampsia/eclampsia compared to that in the age-matched general female population to determine if there is increased risk of RVO in pregnancy. Nationwide population-based retrospective study using data entered into the Korean national health claims database from 2007 to 2011. Of the incident RVO cases in the database, RVO cases that occurred during the pregnancy-associated period, which spanned a 52-week period from 40-weeks-before to 12-weeks-after childbirth, were identified. Of these cases, the presence of pre-eclampsia/eclampsia was determined. The standardized incidence ratios (SIRs) of RVO in the general pregnant population and in the pregnant population with pre-eclampsia/eclampsia were determined with respect to the age-matched general female population. Pregnancy-related RVO was identified in 33 cases from the 1.8 million women who experience childbirth during the study period, while the expected number of cases calculated by the direct standardization to the age-matched general population was 113. Of the 33 patients, 12 patients (36.4%) had pre-eclampsia or eclampsia. The SIR for the general pregnant population in reference to the age-matched general female population was 0.29 (95% CI, 0.20-0.41). In contrast, the SIR for the pregnant population with pre-eclampsia/eclampsia in reference to the age-matched general female population and the age-matched general pregnant population was 67.50 (95% CI, 34.88-117.92) and 246.50 (95% CI, 127.37-430.59), respectively. The results suggest that pre-eclampsia/eclampsia is a risk factor for RVO, while pregnancy itself may not be a risk factor for RVO.