Suppression of TGF-β1/Smad signaling pathway by sesamin contributes to the attenuation of myocardial fibrosis in spontaneously hypertensive rats

This study investigated the effect of sesamin on myocardial fibrosis in spontaneously hypertensive rats (SHRs) and the possible mechanisms involved. Twenty-eight male SHRs were randomly allocated to SHR group, Ses160 group (sesamin 160 mg/kg), Ses80 group (sesamin 80 mg/kg) and Cap30 group (captopri...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0121312-e0121312
Main Authors: Zhao, Mengqiu, Zheng, Shuguo, Yang, Jieren, Wu, Yuanjie, Ren, Younan, Kong, Xiang, Li, Wei, Xuan, Jiali
Format: Article
Language:English
Subjects:
Angiotensin
Angiotensin II
Angiotensin II - blood
Animal tissues
Animals
Antioxidants
Antioxidants - metabolism
Attenuation
Blood pressure
Blood Pressure - drug effects
Captopril
Cardiovascular disease
Collagen
Collagen (type I)
Collagen (type III)
Collagen Type I - metabolism
Collagen Type III - metabolism
Collagens
Deposition
Diabetes
Dioxoles - pharmacology
Drug dosages
Enzymes
Fibroblasts
Fibroblasts - drug effects
Fibroblasts - metabolism
Fibrosis
Gene expression
Growth factors
Heart
Heart diseases
Heart Ventricles - drug effects
Heart Ventricles - physiopathology
Hypertension
Hypertrophy
Laboratory animals
Lignans - pharmacology
Male
Malondialdehyde
Malondialdehyde - metabolism
Myocardium - metabolism
Myocardium - pathology
NAD(P)H oxidase
NADPH Oxidases - metabolism
Organ Size - drug effects
Oxidative stress
Pharmacology
Phosphorylation
Phosphorylation - drug effects
Rats
Rats, Inbred SHR
Rodents
Secretion
Signal transduction
Signal Transduction - drug effects
Signaling
Smad protein
Smad3 protein
Smad3 Protein - metabolism
Smad7 protein
Smad7 Protein - metabolism
Superoxide dismutase
Superoxide Dismutase - metabolism
Systole - drug effects
Transforming growth factor
Transforming Growth Factor beta1 - metabolism
Transforming growth factor-b1
Ventricle
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Summary:This study investigated the effect of sesamin on myocardial fibrosis in spontaneously hypertensive rats (SHRs) and the possible mechanisms involved. Twenty-eight male SHRs were randomly allocated to SHR group, Ses160 group (sesamin 160 mg/kg), Ses80 group (sesamin 80 mg/kg) and Cap30 group (captopril 30 mg/kg). Seven male WKY rats were used as control. Sesamin and captopril were administered intragastrically for 12 weeks. Captopril significantly reduced systolic blood pressure and angiotensin II (Ang II) levels in SHRs, accompanied by a marked attenuation of left ventricular hypertrophy (LVH) and collagen deposition (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0121312