Lipoprotein lipase SNPs rs13702 and rs301 correlate with clinical outcome in chronic lymphocytic leukemia patients

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and is characterized by a heterogeneous clinical course. This variability in clinical course has spiked the search for prognostic markers able to predict patient evolution at the moment of diagnosis. Markers demonstr...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0121526-e0121526
Main Authors: Rombout, Ans, Stamatopoulos, Basile, Lagneaux, Laurence, Lust, Sofie, Offner, Fritz, Naessens, Evelien, Vanderstraeten, Hanne, Verhasselt, Bruno, Philippé, Jan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atherosclerosis
Biomarkers, Tumor - genetics
Bordet, Jules-Jean-Baptiste-Vincent (1870-1961)
Cell cycle
Chronic lymphatic leukemia
Chronic lymphocytic leukemia
Cohort Studies
Deoxyribonucleic acid
DNA
Evolution
Gene expression
Genomes
Genotypes
Hematology
Humans
Immunoglobulin Heavy Chains - genetics
Immunoglobulin Variable Region - genetics
Immunology
Kaplan-Meier Estimate
Kinases
Laboratories
Leukemia
Leukemia, Lymphocytic, Chronic, B-Cell - enzymology
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Lipase
Lipoprotein lipase
Lipoprotein Lipase - genetics
Lipoprotein Lipase - metabolism
Lipoproteins
Lymphatic leukemia
Markers
Medical prognosis
Metabolic disorders
Metabolism
MicroRNAs
Middle Aged
Mutation
Mutation - genetics
Patient outcomes
Patients
Polymorphism, Single Nucleotide - genetics
Prognosis
RNA
RNA, Messenger - genetics
RNA, Messenger - metabolism
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Treatment Outcome
Variable region
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Summary:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and is characterized by a heterogeneous clinical course. This variability in clinical course has spiked the search for prognostic markers able to predict patient evolution at the moment of diagnosis. Markers demonstrated to be of value are the mutation status of the immunoglobulin heavy chain variable region genes (IGHV) and lipoprotein lipase (LPL) expression. High LPL mRNA expression has been associated with short treatment free (TFS) and decreased overall survival (OS) in CLL. The LPL SNPs rs301 (T
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0121526