Clinicopathologic predictors of survival in patients with desmoplastic melanoma

Desmoplastic melanoma is a unique subtype of melanoma which typically affects older patients who often have comorbidities that can adversely affect survival. We sought to identify melanoma-specific factors influencing survival in patients with desmoplastic melanoma. Retrospective review from 1993 to...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0119716-e0119716
Main Authors: Han, Dale, Han, Gang, Zhao, Xiuhua, Rao, Nikhil G, Messina, Jane L, Marzban, Suroosh S, Sarnaik, Amod A, Cruse, C Wayne, Sondak, Vernon K, Zager, Jonathan S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis
Biopsy
Cancer therapies
Care and treatment
Comorbidity
Departments
Fatalities
Female
Histology
Humans
Lymph nodes
Lymphatic Metastasis
Lymphatic system
Male
Medical prognosis
Medicine
Melanoma
Melanoma - diagnosis
Melanoma - mortality
Metastasis
Middle Aged
Neoplasm Invasiveness
Oncology
Pathology
Patient outcomes
Patients
Prognosis
Radiation therapy
Recurrence
Review boards
Skin cancer
Studies
Surgery
Survival
Survival Analysis
Tumors
Young Adult
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Summary:Desmoplastic melanoma is a unique subtype of melanoma which typically affects older patients who often have comorbidities that can adversely affect survival. We sought to identify melanoma-specific factors influencing survival in patients with desmoplastic melanoma. Retrospective review from 1993 to 2011 identified 316 patients with primary desmoplastic melanoma. Clinicopathologic characteristics were correlated with nodal status and outcome. Fifty-five patients (17.4%) had nodal disease: 33 had a positive sentinel lymph node biopsy and 22 developed nodal recurrences (no sentinel lymph node biopsy or false-negative sentinel lymph node biopsy). Nodal disease occurred more often in younger patients and in cases with mixed compared with pure histology (26.7% vs. 14.6%); both of these variables significantly predicted nodal status on multivariable analysis (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0119716