Severe portal hypertension in cirrhosis: evaluation of perfusion parameters with contrast-enhanced ultrasonography

To investigate the role of contrast-enhanced ultrasonography (CEUS) and Doppler ultrasonography (DUS) in the diagnosis of severe portal hypertension (PH) in patients with liver cirrhosis (LC). Patients with PH scheduled to receive hepatic venous pressure gradient (HVPG) measurement were recruited fo...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0121601-e0121601
Main Authors: Jeong, Woo Kyoung, Kim, Tae Yeob, Sohn, Joo Hyun, Kim, Yongsoo, Kim, Jinoo
Format: Article
Language:English
Subjects:
Adult
Ascites
Bile
Cirrhosis
Comparative analysis
Contrast Media
Correlation
Diagnosis
Doppler effect
Female
Hemodynamics
Hospitals
Humans
Hypertension
Hypertension, Portal - diagnostic imaging
Hypertension, Portal - physiopathology
Internal medicine
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - physiopathology
Liver diseases
Male
Medicine
Middle Aged
Patients
Perfusion
Portal hypertension
Portal Vein - diagnostic imaging
Portal Vein - physiopathology
Respiration
ROC Curve
Rodents
Severity of Illness Index
Transit time
Ultrasonography, Doppler
Ultrasound
Ultrasound imaging
Veins & arteries
Velocity
Venous pressure
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Summary:To investigate the role of contrast-enhanced ultrasonography (CEUS) and Doppler ultrasonography (DUS) in the diagnosis of severe portal hypertension (PH) in patients with liver cirrhosis (LC). Patients with PH scheduled to receive hepatic venous pressure gradient (HVPG) measurement were recruited for this study. Hepatic DUS and CEUS were performed successively. Several Doppler and CEUS parameters were explored for correlation with HVPG values and their association with severe PH (≥ 12 mmHg of HVPG). Comparison of the parameters between the severe and non-severe PH groups and their correlation with HVPG values was evaluated. A receiver operating characteristic (ROC) curve analysis was also performed to investigate the performance in order to diagnose severe PH. Fifty-three consecutive patients were enrolled in this study. Among them, 43 patients did not have significant ascites. Compared with the non-severe PH group, portal venous velocity and intrahepatic transit time (ITT) were significantly reduced in the severe PH group (all p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0121601