Autophagic signaling and proteolytic enzyme activity in cardiac and skeletal muscle of spontaneously hypertensive rats following chronic aerobic exercise

Hypertension is a cardiovascular disease associated with deleterious effects in skeletal and cardiac muscle. Autophagy is a degradative process essential to muscle health. Acute exercise can alter autophagic signaling. Therefore, we aimed to characterize the effects of chronic endurance exercise on...

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Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0119382-e0119382
Main Authors: McMillan, Elliott M, Paré, Marie-France, Baechler, Brittany L, Graham, Drew A, Rush, James W E, Quadrilatero, Joe
Format: Article
Language:English
Subjects:
Aerobics
AKT protein
AMP-Activated Protein Kinases - metabolism
Animals
Apoptosis
Autophagy
Blood Pressure
Calpain
Cardiac muscle
Cardiovascular diseases
Caspase
Caspase-3
Cell cycle
Cell death
Endurance
Enzymatic activity
Enzyme activity
Enzyme synthesis
Enzymes
Exercise
Fitness equipment
Fitness training programs
Forkhead Box Protein O3
Forkhead Transcription Factors - metabolism
Gene expression
Gene Expression Regulation, Enzymologic
Heart diseases
Heart failure
Hypertension
Kinases
Kinesiology
Male
mRNA
Muscle, Skeletal - enzymology
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscles
Musculoskeletal system
Myocardium - enzymology
Myocardium - metabolism
Myocardium - pathology
p62 Protein
Peptide Hydrolases - genetics
Peptide Hydrolases - metabolism
Phagocytosis
Phosphorylation
Physical Conditioning, Animal
Physical fitness
Physical training
Proteasomes
Proteins
Proteolysis
Proto-Oncogene Proteins c-akt - metabolism
Quantitative analysis
Rats
Rats, Inbred SHR
Reactive Oxygen Species - metabolism
Ribosomal Protein S6 Kinases, 70-kDa - metabolism
RNA
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
Running
Signal Transduction
Signaling
Skeletal muscle
Time Factors
Training
Ubiquitin - genetics
Ubiquitin - metabolism
Ventricle
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Summary:Hypertension is a cardiovascular disease associated with deleterious effects in skeletal and cardiac muscle. Autophagy is a degradative process essential to muscle health. Acute exercise can alter autophagic signaling. Therefore, we aimed to characterize the effects of chronic endurance exercise on autophagy in skeletal and cardiac muscle of normotensive and hypertensive rats. Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were assigned to a sedentary condition or 6 weeks of treadmill running. White gastrocnemius (WG) of hypertensive rats had higher (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0119382