Dose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry

Cigarette smoking is an important modifiable risk factor for cardiovascular diseases. However, the effect of smoking and its cessation on glycemic control in diabetic patients has not been fully examined yet. The aim of the present study was to examine the association of smoking status with glycemic...

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Published in:PloS one 2015-03, Vol.10 (3), p.e0122023-e0122023
Main Authors: Ohkuma, Toshiaki, Iwase, Masanori, Fujii, Hiroki, Kaizu, Shinako, Ide, Hitoshi, Jodai, Tamaki, Kikuchi, Yohei, Idewaki, Yasuhiro, Hirakawa, Yoichiro, Nakamura, Udai, Kitazono, Takanari
Format: Article
Language:English
Subjects:
Aged
Analysis
Blood Glucose - metabolism
Body mass
C-reactive protein
Cardiovascular diseases
Cigarette smoking
Cigarettes
Cross-Sectional Studies
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes therapy
Diabetics
Drug addiction
Energy intake
Fasting
Glucose
Health risk assessment
Health risks
Heart diseases
Hemoglobin
Homeostasis
Humans
Insulin
Insulin Resistance
Japan
Male
Markers
Mental depression
Middle Aged
Patients
Proteins
Registries
Research design
Risk factors
Science
Secretion
Sensitivity analysis
Smoking
Smoking - adverse effects
Smoking Cessation
Studies
Time dependence
Type 2 diabetes
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Summary:Cigarette smoking is an important modifiable risk factor for cardiovascular diseases. However, the effect of smoking and its cessation on glycemic control in diabetic patients has not been fully examined yet. The aim of the present study was to examine the association of smoking status with glycemic level and markers of insulin resistance and secretion in patients with type 2 diabetes mellitus. A total of 2,490 Japanese male patients with type 2 diabetes mellitus aged ≥20 years were divided according to smoking status, amount of cigarettes smoked and years since quitting. The associations with glycemic level and markers of insulin resistance and secretion were examined cross-sectionally. HbA1c levels increased progressively with increases in both number of cigarettes per day and pack-years of cigarette smoking compared with never smokers (P for trend = 0.001 and
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0122023