Effects of cyclic tensile strain on chondrocyte metabolism: a systematic review

Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix ada...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0119816-e0119816
Main Authors: Bleuel, Judith, Zaucke, Frank, Brüggemann, Gert-Peter, Niehoff, Anja
Format: Article
Language:English
Subjects:
Arthritis
Biological effects
Biomechanics
Cartilage
Cartilage (articular)
Cell culture
Chondrocytes
Chondrocytes - metabolism
Experiments
Extracellular matrix
Gene expression
Humans
Inflammation
Metabolism
Reviews
Strain
Stress, Mechanical
Tensile Strength
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix adapt in what ways, and how specific loading characteristics affect matrix changes. This review focuses on the influence of cyclic tensile strain on chondrocyte metabolism in vitro. It also aimed to identify anabolic or catabolic chondrocyte responses to different loading protocols. The key findings show that loading cells up to 3% strain, 0.17 Hz, and 2 h, resulted in weak or no biological responses. Loading between 3-10% strain, 0.17-0.5 Hz, and 2-12 h led to anabolic responses; and above 10% strain, 0.5 Hz, and 12 h catabolic events predominated. However, this review also discusses that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0119816