High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with proliferative diabetic retinopathy

Little is known about the relationship between lower extremity peripheral arterial disease (PAD) and proliferative diabetic retinopathy (PDR) in type 2 diabetes (T2D). Here, we explored the relationship between sight-threatening PDR and PAD. We screened for diabetic retinopathy (DR) and PAD in hospi...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-03, Vol.10 (3), p.e0122022-e0122022
Main Authors: Chen, Yi-Wen, Wang, Ying-Ying, Zhao, Dong, Yu, Cai-Guo, Xin, Zhong, Cao, Xi, Shi, Jing, Yang, Guang-Ran, Yuan, Ming-Xia, Yang, Jin-Kui
Format: Article
Language:English
Subjects:
Aged
Ankle
Ankle Brachial Index
Blood pressure
Cardiology
Cardiovascular disease
Cholesterol
Coronary vessels
Correlation coefficients
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Doppler effect
Endocrinology
Epidermal growth factor receptors
Female
Glucose
Hemoglobin
Hispanic Americans
Hospitals
Humans
Ischemia
Laboratories
Lower Extremity - blood supply
Male
Middle Aged
Ophthalmology
Patients
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - epidemiology
Prevalence
Prevalence studies (Epidemiology)
Retina
Retinopathy
Statistical analysis
Type 2 diabetes
Ultrasonography, Doppler
Ultrasound
Vascular diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Little is known about the relationship between lower extremity peripheral arterial disease (PAD) and proliferative diabetic retinopathy (PDR) in type 2 diabetes (T2D). Here, we explored the relationship between sight-threatening PDR and PAD. We screened for diabetic retinopathy (DR) and PAD in hospitalized patients with T2D. Patients with a diabetic duration of more than 10 years, HbA1c ≥7.5%, eGFR ≥60 mL/min/1.73 m2 and with PDR or with no diabetic retinopathy (NDR) were eligible for this cross-sectional study. Severities of DR were graded by digital retinal photographs according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. We assessed PAD by measuring Ankle Brachial Index (ABI), Toe Brachial Index (TBI) and Doppler ultrasound. Statistical analyses were performed using SPSS 17.0 software. Of the 1544 patients, 169 patients with extreme eye (57 PDR and 112 NDR) phenotypes met the inclusion criteria. Patients with PDR had a significantly higher proportion of low ABI (≤0.99) and high ABI (≥1.3) than patients with NDR (28.1% and 15.8% vs. 14.3% and 6.2% respectively, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0122022