Different prognostic values of plasma Epstein-Barr virus DNA and maximal standardized uptake value of 18F-FDG PET/CT for nasopharyngeal carcinoma patients with recurrence

To evaluate and compare the prognostic value of Epstein-Barr virus (EBV) DNA and maximal standard uptake values (SUVmax ) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) in subgroups of nasopharyngeal carcinoma (NPC) patients with locoregional or distant recurrence. A tota...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0122756-e0122756
Main Authors: Shen, Ting, Tang, Lin-Quan, Luo, Dong-Hua, Chen, Qiu-Yan, Li, Pei-Jing, Mai, Dong-Mei, Guo, Shan-Shan, Liu, Li-Ting, Qian, Chao-Nan, Guo, Xiang, Zeng, Mu-Sheng, Mo, Hao-Yuan, Mai, Hai-Qiang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Bioindicators
Biomarkers
Cancer therapies
Carcinoma
Chemotherapy
Child
Collaboration
Deoxyribonucleic acid
DNA
DNA methylation
DNA, Viral - blood
Epstein-Barr virus
Epstein-Barr Virus Infections - blood
Epstein-Barr Virus Infections - pathology
Epstein-Barr Virus Infections - virology
Female
Fluorodeoxyglucose F18 - administration & dosage
Glucose
Hazards
Head & neck cancer
Herpesvirus 4, Human - genetics
Humans
Laboratories
Male
Medical prognosis
Medical research
Metastasis
Middle Aged
Multivariate analysis
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - blood
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - virology
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - virology
Neoplasm Staging
Nuclear medicine
Oncology
Patients
Plasma
Positron emission
Positron emission tomography
Prognosis
Radiation therapy
Regression analysis
Regression models
Salvage
Subgroups
Survival
Throat cancer
Tomography
Tomography, X-Ray Computed
Viruses
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Summary:To evaluate and compare the prognostic value of Epstein-Barr virus (EBV) DNA and maximal standard uptake values (SUVmax ) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) in subgroups of nasopharyngeal carcinoma (NPC) patients with locoregional or distant recurrence. A total of 194 patients with recurrent NPC (locoregional recurrence: 107, distant recurrence: 87) were enrolled. Patients took evidence of recurrence performed with 18F-FDG-PET and an EBV DNA test before salvage treatment. Clinical parameters, the status of EBV DNA and the value of SUVmax were used for survival analysis using the Kaplan-Meier method and the Cox proportional hazards regression model. In the subgroup of patients with locoregional recurrence, patients with SUVmax
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0122756