Orthokeratology to control myopia progression: a meta-analysis

To evaluate the clinical treatment effects of orthokeratology to slow the progression of myopia. Several well-designed controlled studies have investigated the effects of orthokeratology in school-aged children. We conducted this meta-analysis to better evaluate the existing evidence. Relevant studi...

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Published in:PloS one 2015-04, Vol.10 (4), p.e0124535
Main Authors: Sun, Yuan, Xu, Fan, Zhang, Ting, Liu, Manli, Wang, Danyang, Chen, Yile, Liu, Quan
Format: Article
Language:English
Subjects:
Analysis
Axial Length, Eye - physiology
Care and treatment
Child
Children
Complications and side effects
Confidence intervals
Control methods
Development and progression
Geographical distribution
Humans
MEDLINE
Meta-analysis
Myopia
Myopia, Degenerative - prevention & control
Neovascularization
Orthokeratologic Procedures - methods
Orthokeratologic Procedures - standards
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cited_by cdi_FETCH-LOGICAL-c758t-75be1eb6ced3130cea0b951c474a59ca9b9f108cd0cce597e0dc488daec1fc3d3
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creator Sun, Yuan
Xu, Fan
Zhang, Ting
Liu, Manli
Wang, Danyang
Chen, Yile
Liu, Quan
description To evaluate the clinical treatment effects of orthokeratology to slow the progression of myopia. Several well-designed controlled studies have investigated the effects of orthokeratology in school-aged children. We conducted this meta-analysis to better evaluate the existing evidence. Relevant studies were identified in the Medline and Embase database without language limitations. The main outcomes included axial length and vitreous chamber depth reported as the mean ± standard deviation. The results were pooled and assessed with a fixed-effects model analysis. Subgroup analyses were performed according to geographical location and study design. Of the seven eligible studies, all reported axial length changes after 2 years, while two studies reported vitreous chamber depth changes. The pooled estimates indicated that change in axial length in the ortho-k group was 0.27 mm (95% confidence interval [CI]: 0.22, 0.32) less than the control group. Myopic progression was reduced by approximately 45%. The combined results revealed that the difference in vitreous chamber depth between the two groups was 0.22 mm (95% confidence interval [CI]: 0.14, 0.31). None of the studies reported severe adverse events. The overall findings suggest that ortho-k can slow myopia progression in school-aged children.
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subjects Analysis
Axial Length, Eye - physiology
Care and treatment
Child
Children
Complications and side effects
Confidence intervals
Control methods
Development and progression
Geographical distribution
Humans
MEDLINE
Meta-analysis
Myopia
Myopia, Degenerative - prevention & control
Neovascularization
Orthokeratologic Procedures - methods
Orthokeratologic Procedures - standards
title Orthokeratology to control myopia progression: a meta-analysis
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