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Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study

Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published,...

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Published in:PloS one 2015-04, Vol.10 (4), p.e0124239-e0124239
Main Authors: Márquez-Rodas, Iván, Martín González, Manuel, Nagore, Eduardo, Gómez-Fernández, Cristina, Avilés-Izquierdo, Jose Antonio, Maldonado-Seral, Cayetana, Soriano, Virtudes, Majem-Tarruella, Margarita, Palomar, Virginia, Maseda, Rocio, Martín-Carnicero, Alfonso, Puertolas, Teresa, Godoy, Elena, Cerezuela, Pablo, Ochoa de Olza, Maria, Campos, Begoña, Perez-Ruiz, Elisabeth, Soria, Ainara, Gil-Arnaiz, Irene, Gonzalez-Cao, Maria, Galvez, Elisa, Arance, Ana, Belon, Joaquin, de la Cruz-Merino, Luis, Martín-Algarra, Salvador
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cited_by cdi_FETCH-LOGICAL-c734t-303b60f8ab7f6db702bd1211b754c475a22c0c18471cdc2a2ba42ea7a9f71e373
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creator Márquez-Rodas, Iván
Martín González, Manuel
Nagore, Eduardo
Gómez-Fernández, Cristina
Avilés-Izquierdo, Jose Antonio
Maldonado-Seral, Cayetana
Soriano, Virtudes
Majem-Tarruella, Margarita
Palomar, Virginia
Maseda, Rocio
Martín-Carnicero, Alfonso
Puertolas, Teresa
Godoy, Elena
Cerezuela, Pablo
Ochoa de Olza, Maria
Campos, Begoña
Perez-Ruiz, Elisabeth
Soria, Ainara
Gil-Arnaiz, Irene
Gonzalez-Cao, Maria
Galvez, Elisa
Arance, Ana
Belon, Joaquin
de la Cruz-Merino, Luis
Martín-Algarra, Salvador
description Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior.
doi_str_mv 10.1371/journal.pone.0124239
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Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. 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Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). 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Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>ProQuest Publicly Available Content database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Márquez-Rodas, Iván</au><au>Martín González, Manuel</au><au>Nagore, Eduardo</au><au>Gómez-Fernández, Cristina</au><au>Avilés-Izquierdo, Jose Antonio</au><au>Maldonado-Seral, Cayetana</au><au>Soriano, Virtudes</au><au>Majem-Tarruella, Margarita</au><au>Palomar, Virginia</au><au>Maseda, Rocio</au><au>Martín-Carnicero, Alfonso</au><au>Puertolas, Teresa</au><au>Godoy, Elena</au><au>Cerezuela, Pablo</au><au>Ochoa de Olza, Maria</au><au>Campos, Begoña</au><au>Perez-Ruiz, Elisabeth</au><au>Soria, Ainara</au><au>Gil-Arnaiz, Irene</au><au>Gonzalez-Cao, Maria</au><au>Galvez, Elisa</au><au>Arance, Ana</au><au>Belon, Joaquin</au><au>de la Cruz-Merino, Luis</au><au>Martín-Algarra, Salvador</au><au>Slominski, Andrzej T</au><aucorp>Spanish Multidisciplinary Group of Melanoma (GEM)</aucorp><aucorp>Spanish Multidisciplinary Group of Melanoma (GEM)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-13</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0124239</spage><epage>e0124239</epage><pages>e0124239-e0124239</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25874698</pmid><doi>10.1371/journal.pone.0124239</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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1932-6203
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source PubMed Central Free; ProQuest Publicly Available Content database
subjects Analysis
Biomarkers
Children
Criteria
Càncer de pàncrees
Dermatology
Espanya
Female
Genetic aspects
Genetic counseling
Genetic Predisposition to Disease
Genetics
Health aspects
Health risks
Humans
Incidence
Male
Medical diagnosis
Melanoma
Melanoma - epidemiology
Melanoma - pathology
Melanoma, Cutaneous Malignant
Middle Aged
Mitosis
Multivariate Analysis
Mutation
Pancreas cancer
Pancreatic cancer
Pathology
Patients
Risk analysis
Risk Factors
Skin cancer
Skin Neoplasms - epidemiology
Skin Neoplasms - pathology
Spain
Spain - epidemiology
Studies
title Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study
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