Insulin resistance change and antiretroviral therapy exposure in HIV-infected and uninfected Rwandan women: a longitudinal analysis

We longitudinally assessed predictors of insulin resistance (IR) change among HIV-uninfected and HIV-infected (ART-initiators and ART-non-initiators) Rwandan women. HIV-infected (HIV+) and uninfected (HIV-) women provided demographic and clinical measures: age, body mass index (BMI) in Kg/(height in...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0123936
Main Authors: Mutimura, Eugene, Hoover, Donald R, Shi, Qiuhu, Dusingize, Jean Claude, Sinayobye, Jean D'Amour, Cohen, Mardge, Anastos, Kathryn
Format: Article
Language:English
Subjects:
Adult
Analysis
Anti-HIV Agents - adverse effects
Anti-HIV Agents - pharmacology
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiretroviral Therapy, Highly Active - adverse effects
Antiretroviral Therapy, Highly Active - methods
Body fat
Body mass
Body Mass Index
Body size
Case-Control Studies
CD4 Lymphocyte Count
Demographics
Diabetes
Diabetes therapy
Exposure
Fat-free body mass
Female
Glucose
Highly active antiretroviral therapy
HIV
HIV infections
HIV Infections - drug therapy
HIV Infections - physiopathology
HIV patients
HIV Seropositivity
Homeostasis
Human immunodeficiency virus
Humans
Initiators
Insulin
Insulin - blood
Insulin Resistance
Longitudinal Studies
Measuring instruments
Middle Aged
Prospective Studies
Regression analysis
Regression models
Rwanda
Zidovudine
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Summary:We longitudinally assessed predictors of insulin resistance (IR) change among HIV-uninfected and HIV-infected (ART-initiators and ART-non-initiators) Rwandan women. HIV-infected (HIV+) and uninfected (HIV-) women provided demographic and clinical measures: age, body mass index (BMI) in Kg/(height in meters)2, Fat-Mass (FMI) and Fat-Free-Mass (FFMI) index, fasting serum glucose and insulin. Homeostasis Model Assessment (HOMA) was calculated to estimate IR change over time in log10 transformed HOMA measured at study enrollment or prior to ART initiation in 3 groups: HIV- (n = 194), HIV+ ART-non-initiators (n=95) and HIV+ ART-initiators (n=371). ANCOVA linear regression models of change in log10-HOMA were fit with all models included the first log10 HOMA as a predictor. Mean±SD log10-HOMA was -0.18±0.39 at the 1st and -0.21±0.41 at the 2nd measure, with mean change of 0.03±0.44. In the final model (all women) BMI at 1st HOMA measure (0.014; 95% CI=0.006-0.021 per kg/m2; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0123936