Structural brain changes after traditional and robot-assisted multi-domain cognitive training in community-dwelling healthy elderly

The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Parti...

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Published in:PloS one 2015-04, Vol.10 (4), p.e0123251-e0123251
Main Authors: Kim, Geon Ha, Jeon, Seun, Im, Kiho, Kwon, Hunki, Lee, Byung Hwa, Kim, Ga Young, Jeong, Hana, Han, Noh Eul, Seo, Sang Won, Cho, Hanna, Noh, Young, Park, Sang Eon, Kim, Hojeong, Hwang, Jung Won, Yoon, Cindy W, Kim, Hee Jin, Ye, Byoung Seok, Chin, Ju Hee, Kim, Jung-Hyun, Suh, Mee Kyung, Lee, Jong Min, Kim, Sung Tae, Choi, Mun-Taek, Kim, Mun Sang, Heilman, Kenneth M, Jeong, Jee Hyang, Na, Duk L
Format: Article
Language:English
Subjects:
Age
Aged
Brain
Brain - pathology
Cognition
Cognitive ability
Cognitive Therapy - methods
Cortex
Dementia - prevention & control
Elderly
Female
Geriatrics
Humans
Independent Living
Male
Middle Aged
Older people
Organ Size
Robotics
Robots
Thinning
Training
Treatment Outcome
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cited_by cdi_FETCH-LOGICAL-c758t-50f8c7879602ab81a898b5e7c355d69a23985e5722184ad22457d1075de260173
cites cdi_FETCH-LOGICAL-c758t-50f8c7879602ab81a898b5e7c355d69a23985e5722184ad22457d1075de260173
container_end_page e0123251
container_issue 4
container_start_page e0123251
container_title PloS one
container_volume 10
creator Kim, Geon Ha
Jeon, Seun
Im, Kiho
Kwon, Hunki
Lee, Byung Hwa
Kim, Ga Young
Jeong, Hana
Han, Noh Eul
Seo, Sang Won
Cho, Hanna
Noh, Young
Park, Sang Eon
Kim, Hojeong
Hwang, Jung Won
Yoon, Cindy W
Kim, Hee Jin
Ye, Byoung Seok
Chin, Ju Hee
Kim, Jung-Hyun
Suh, Mee Kyung
Lee, Jong Min
Kim, Sung Tae
Choi, Mun-Taek
Kim, Mun Sang
Heilman, Kenneth M
Jeong, Jee Hyang
Na, Duk L
description The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly. ClnicalTrials.gov NCT01596205.
doi_str_mv 10.1371/journal.pone.0123251
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Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly. 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Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Geon Ha</au><au>Jeon, Seun</au><au>Im, Kiho</au><au>Kwon, Hunki</au><au>Lee, Byung Hwa</au><au>Kim, Ga Young</au><au>Jeong, Hana</au><au>Han, Noh Eul</au><au>Seo, Sang Won</au><au>Cho, Hanna</au><au>Noh, Young</au><au>Park, Sang Eon</au><au>Kim, Hojeong</au><au>Hwang, Jung Won</au><au>Yoon, Cindy W</au><au>Kim, Hee Jin</au><au>Ye, Byoung Seok</au><au>Chin, Ju Hee</au><au>Kim, Jung-Hyun</au><au>Suh, Mee Kyung</au><au>Lee, Jong Min</au><au>Kim, Sung Tae</au><au>Choi, Mun-Taek</au><au>Kim, Mun Sang</au><au>Heilman, Kenneth M</au><au>Jeong, Jee Hyang</au><au>Na, Duk L</au><au>Amitay, Sygal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural brain changes after traditional and robot-assisted multi-domain cognitive training in community-dwelling healthy elderly</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-21</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0123251</spage><epage>e0123251</epage><pages>e0123251-e0123251</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly. ClnicalTrials.gov NCT01596205.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25898367</pmid><doi>10.1371/journal.pone.0123251</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2015-04, Vol.10 (4), p.e0123251-e0123251
issn 1932-6203
1932-6203
language eng
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source Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central
subjects Age
Aged
Brain
Brain - pathology
Cognition
Cognitive ability
Cognitive Therapy - methods
Cortex
Dementia - prevention & control
Elderly
Female
Geriatrics
Humans
Independent Living
Male
Middle Aged
Older people
Organ Size
Robotics
Robots
Thinning
Training
Treatment Outcome
title Structural brain changes after traditional and robot-assisted multi-domain cognitive training in community-dwelling healthy elderly
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