Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study

• Published in: PloS one 2015-04, Vol.10 (4), p.e0124772-e0124772
• Main Authors: Gupta, Jayanta, Dominic, Elizabeth A, Fink, Jeffrey C, Ojo, Akinlolu O, Barrows, Ian R, Reilly, Muredach P, Townsend, Raymond R, Joffe, Marshall M, Rosas, Sylvia E, Wolman, Melanie, Patel, Samir S, Keane, Martin G, Feldman, Harold I, Kusek, John W, Raj, Dominic S
• Format: Article
• Language: English
• Subjects: Adult; Aged; Albumin; Analysis; Atherosclerosis; Biomarkers; Biomarkers - blood; Blood diseases; Blood pressure; C-reactive protein; Chronic kidney failure; Cohort Studies; Creatinine; Cytokines; Diabetes mellitus; Echocardiography; Electrolytes; Epidemiology; Family medical history; Female; Fibrin; Fibrinogen; Geometry; Glomerular filtration rate; Health aspects; Heart diseases; Heart failure; Heart hypertrophy; Humans; Hypertension; Hypertrophy; Hypertrophy, Left Ventricular - complications; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - physiopathology; Inflammation; Inflammation Mediators - blood; Interleukin; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 6; Kidney diseases; Kidneys; Logistic Models; Male; Medical research; Medicine; Middle Aged; Minority & ethnic groups; Mortality; Muscle contraction; Myocardium - pathology; Nephrology; Patients; Plasma levels; Prospective Studies; Proteins; Regression analysis; Renal insufficiency; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - pathology; Risk Factors; Serum albumin; Smoking; TNF inhibitors; Transforming growth factor; Transforming growth factors; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Ventricle
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0124772

Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function. Plasma levels of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-6, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, high-sensitivity C-Reactive protein (hs-CRP), fibrinogen and serum albumin were measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Echocardiography was performed according to the recommendations of the American Society of Echocardiography and interpreted at a centralized core laboratory. LVH, systolic dysfunction and diastolic dysfunction were present in 52.3%, 11.8% and 76.3% of the study subjects, respectively. In logistic regression analysis adjusted for age, sex, race/ethnicity, diabetic status, current smoking status, systolic blood pressure, urinary albumin- creatinine ratio and estimated glomerular filtration rate, hs-CRP (OR 1.26 [95% CI 1.16, 1.37], p