Correlation of a decline in aerobic capacity with development of emphysema in patients with chronic obstructive pulmonary disease: a prospective observational study

In patients with COPD, CT assessment of emphysema and airway disease is known to be associated with lung function and 6-minute walk distance. However, it remains to be determined whether low attenuation area (LAA) on CT is associated with aerobic capacity assessed using cardiopulmonary exercise test...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0125053-e0125053
Main Authors: Yamasawa, Wakako, Tasaka, Sadatomo, Betsuyaku, Tomoko, Yamaguchi, Kazuhiro
Format: Article
Language:English
Subjects:
Aerobic capacity
Aged
Aorta
Aortic arch
Bifurcations
Carbon dioxide
Carbon Dioxide - metabolism
Care and treatment
Chronic obstructive pulmonary disease
Correlation
Correlation analysis
Emphysema
Exercise Test - methods
Exercise Tolerance - physiology
Female
Forced Expiratory Volume - physiology
Humans
Lung - metabolism
Lung - physiopathology
Lung diseases
Lungs
Male
Medical research
Observational studies
Obstructive lung disease
Oxygen
Oxygen - metabolism
Oxygen content
Patients
Prospective Studies
Pulmonary Disease, Chronic Obstructive - metabolism
Pulmonary Disease, Chronic Obstructive - physiopathology
Pulmonary Emphysema - metabolism
Pulmonary Emphysema - physiopathology
Respiratory function
Respiratory tract diseases
Saturation
Severity of Illness Index
Statistics
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Summary:In patients with COPD, CT assessment of emphysema and airway disease is known to be associated with lung function and 6-minute walk distance. However, it remains to be determined whether low attenuation area (LAA) on CT is associated with aerobic capacity assessed using cardiopulmonary exercise testing (CPET). In this prospective observational study, we repeatedly conducted high-resolution CT and CPET using a treadmill in 81 COPD patients over a median interval of 3.5 years. Two investigators independently scored LAA on images obtained at the aortic arch level, tracheal bifurcation level, and supradiaphragmatic level. Grades for the images of each lung were added to yield the total LAA score. Total LAA score was negatively correlated with peak aerobic capacity ([Formula: see text]) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0125053