Restoring susceptibility induced MRI signal loss in rat brain at 9.4 T: A step towards whole brain functional connectivity imaging

The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture intr...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0119450-e0119450
Main Authors: Li, Rupeng, Liu, Xiping, Sidabras, Jason W, Paulson, Eric S, Jesmanowicz, Andrzej, Nencka, Andrew S, Hudetz, Anthony G, Hyde, James S
Format: Article
Language:English
Subjects:
Amygdala
Analysis
Animals
Biophysics
Brain
Brain - diagnostic imaging
Brain - physiology
Brain Mapping - methods
Brain Mapping - veterinary
Brain research
Cortex (insular)
Ear, Middle - chemistry
Echo-Planar Imaging - methods
Echo-Planar Imaging - veterinary
Fluorocarbons - administration & dosage
Image Processing, Computer-Assisted - methods
Laboratory animals
Limbic system
Liquid phases
Magnetic fields
Magnetic permeability
Magnetic resonance imaging
Magnetic susceptibility
Medical imaging
Medical research
Middle ear
Nervous system
Neural networks
Neuroimaging
Perfluorocarbons
Radiography
Rats
Seeds
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Summary:The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0119450