Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task

• Published in: PloS one 2015-04, Vol.10 (4), p.e0122063-e0122063
• Main Authors: Tedford, Stephanie E, Persons, Amanda L, Napier, T Celeste
• Format: Article
• Language: English
• Subjects: Addictions; Addictive behaviors; Animals; Apathy; Attention deficit hyperactivity disorder; Behavior; Behavior, Animal; Choice Behavior; Circuits; Cocaine; Corpus Striatum - physiopathology; Decision making; Delay time; Dopamine; Dopamine - metabolism; Dopamine receptors; Electric Stimulation; Hypothalamus; Hypothalamus (lateral); Hypothalamus - physiopathology; Impulsive Behavior; Impulsivity; Intracranial self-stimulation; Laboratory animals; Lesions; Male; Metabolism; Methamphetamine; Neostriatum; Operant conditioning; Parkinson's disease; Pharmacology; Pressing; Psychopharmacology; Rats; Rats, Sprague-Dawley; Reinforcement; Self Stimulation; Substrates; Synaptic Transmission
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0122063

Dysregulated dopamine transmission in striatal circuitry is associated with impulsivity. The current study evaluated the influence of dopaminergic inputs to the dorsolateral striatum on impulsive choice, one aspect of impulsive behavior. We implemented an operant task that measures impulsive choice in rats via delay discounting wherein intracranial self-stimulation (ICSS) was used as the positive reinforcer. To do so, rats were anesthetized to allow implanting of a stimulating electrode within the lateral hypothalamus of one hemisphere and bilateral dorsal striatal injections of the dopaminergic toxin, 6-OHDA (lesioned) or its vehicle (sham). Following recovery, rats were trained in a delay discounting task wherein they selected between a small ICSS current presented immediately after lever pressing, and a large ICSS current presented following a 0 to 15 s delay upon pressing the alternate lever. Task acquisition and reinforcer discrimination were similar for lesioned and sham rats. All rats exhibited an initial preference for the large reinforcer, and as the delay was increased, preference for the large reinforcer was decreased indicating that the subjective value of the large reinforcer was discounted as a function of delay time. However, this discounting effect was significantly enhanced in lesioned rats for the longer delays. These data reveal a contribution of dopaminergic inputs to the dorsolateral striatum on impulsive choice behavior, and provide new insights into neural substrates underlying discounting behaviors.