Efficacy of a contact lens sensor for monitoring 24-h intraocular pressure related patterns

To study performance of a contact lens sensor (CLS) for 24-hour monitoring of IOP-related short-term patterns and compare with IOP obtained by pneumatonometry. Prospective clinical trial. Thirty-one healthy volunteers and 2 glaucoma patients were housed for 24 hours in a sleep laboratory. One random...

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Published in:PloS one 2015-05, Vol.10 (5), p.e0125530-e0125530
Main Authors: Mansouri, Kaweh, Weinreb, Robert N, Liu, John H K
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Contact Lenses
Contact pressure
Diabetic retinopathy
Eye
Eye (anatomy)
Eye lens
Female
Glaucoma
Glaucoma - diagnosis
Heart Rate
Humans
Hypertension
Intraocular Pressure
Male
Measurement
Middle Aged
Monitoring
Physiological aspects
Reproducibility of Results
Sensors
Sitting position
Sleep
Sleep and wakefulness
Slopes
Strain gauges
Technology application
Time Factors
Tonometry, Ocular - methods
Young Adult
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description To study performance of a contact lens sensor (CLS) for 24-hour monitoring of IOP-related short-term patterns and compare with IOP obtained by pneumatonometry. Prospective clinical trial. Thirty-one healthy volunteers and 2 glaucoma patients were housed for 24 hours in a sleep laboratory. One randomly selected eye was fitted with a CLS (Triggerfish, Sensimed, Switzerland), which measures changes in ocular circumference. In the contralateral eye, IOP measurements were taken using a pneumatonometer every two hours with subjects in the habitual body positions. Heart rate (HR) was measured 3 times during the night for periods of 6 minutes separated by 2 hours. Performance of CLS was defined in two ways: 1) recording the known pattern of IOP increase going from awake (sitting position) to sleep (recumbent), defined as the wake/sleep (W/S) slope and 2) accuracy of the ocular pulse frequency (OPF) concurrent to that of the HR interval. Strength of association between overall CLS and pneumatonometer curves was assessed using coefficients of determination (R2). The W/S slope was statistically significantly positive in both eyes of each subject (CLS, 57.0 ± 40.5 mVeq/h, p
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Prospective clinical trial. Thirty-one healthy volunteers and 2 glaucoma patients were housed for 24 hours in a sleep laboratory. One randomly selected eye was fitted with a CLS (Triggerfish, Sensimed, Switzerland), which measures changes in ocular circumference. In the contralateral eye, IOP measurements were taken using a pneumatonometer every two hours with subjects in the habitual body positions. Heart rate (HR) was measured 3 times during the night for periods of 6 minutes separated by 2 hours. Performance of CLS was defined in two ways: 1) recording the known pattern of IOP increase going from awake (sitting position) to sleep (recumbent), defined as the wake/sleep (W/S) slope and 2) accuracy of the ocular pulse frequency (OPF) concurrent to that of the HR interval. Strength of association between overall CLS and pneumatonometer curves was assessed using coefficients of determination (R2). The W/S slope was statistically significantly positive in both eyes of each subject (CLS, 57.0 ± 40.5 mVeq/h, p&lt;0.001 and 1.6 ± 0.9 mmHg/h, p&lt;0.05 in the contralateral eye). In all, 87 CLS plots concurrent to the HR interval were evaluated. Graders agreed on evaluability for OPF in 83.9% of CLS plots. Accuracy of the CLS to detect the OPF was 86.5%. Coefficient of correlation between CLS and pneumatonometer for the mean 24-h curve was R2 = 0.914. CLS measurements compare well to the pneumatonometer and may be of practical use for detection of sleep-induced IOP changes. The CLS also is able to detect ocular pulsations with good accuracy in a majority of eyes. 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The W/S slope was statistically significantly positive in both eyes of each subject (CLS, 57.0 ± 40.5 mVeq/h, p&lt;0.001 and 1.6 ± 0.9 mmHg/h, p&lt;0.05 in the contralateral eye). In all, 87 CLS plots concurrent to the HR interval were evaluated. Graders agreed on evaluability for OPF in 83.9% of CLS plots. Accuracy of the CLS to detect the OPF was 86.5%. Coefficient of correlation between CLS and pneumatonometer for the mean 24-h curve was R2 = 0.914. CLS measurements compare well to the pneumatonometer and may be of practical use for detection of sleep-induced IOP changes. The CLS also is able to detect ocular pulsations with good accuracy in a majority of eyes. ClinicalTrials.gov NCT01390779.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25942434</pmid><doi>10.1371/journal.pone.0125530</doi><oa>free_for_read</oa></addata></record>
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source Access via ProQuest (Open Access); PubMed Central
subjects Adult
Case-Control Studies
Contact Lenses
Contact pressure
Diabetic retinopathy
Eye
Eye (anatomy)
Eye lens
Female
Glaucoma
Glaucoma - diagnosis
Heart Rate
Humans
Hypertension
Intraocular Pressure
Male
Measurement
Middle Aged
Monitoring
Physiological aspects
Reproducibility of Results
Sensors
Sitting position
Sleep
Sleep and wakefulness
Slopes
Strain gauges
Technology application
Time Factors
Tonometry, Ocular - methods
Young Adult
title Efficacy of a contact lens sensor for monitoring 24-h intraocular pressure related patterns
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