Clinical and laboratory studies of the fate of intranasal allergen

The precise way in which allergen is handled by the nose is unknown. The objective of this study was to determine recovery of Der p 1 allergen following nasal administration and to determine whether Der p 1 can be detected in nasal biopsies after natural exposure and nasal challenge to allergen. (1)...

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Bibliographic Details
Published in:PloS one 2015-05, Vol.10 (5), p.e0127477-e0127477
Main Authors: Rimmer, Janet, Santos, Conceição, Yli-Panula, Eija, Noronha, Virginia, Viander, Markku
Format: Article
Language:English
Subjects:
Adult
Air pollution
Allergens
Allergens - metabolism
Allergies
Allergy
Analysis
Animals
Asthma
Atopy
Carbon particles
Care and treatment
Charcoal
Compartments
Dendritic cells
Deposition
Der p 1 antigen
Dermatophagoides pteronyssinus - immunology
Diagnosis
Enzyme-linked immunosorbent assay
Eosinophils
Epithelium
Exposure
Female
Glands
Humans
Hypersensitivity
Immunoglobulin E
Immunology
Inflammation
Inflammatory response
Intranasal administration
Lamina propria
Leukocytes (eosinophilic)
Macrophages
Male
Medical research
Medical schools
Middle Aged
Mucosa
Mucus
Nasal Mucosa - metabolism
Nose
Nose - immunology
Nose - metabolism
Particulates
Position (location)
Recovery
Risk factors
Sputum
Staining
Studies
Young Adult
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Summary:The precise way in which allergen is handled by the nose is unknown. The objective of this study was to determine recovery of Der p 1 allergen following nasal administration and to determine whether Der p 1 can be detected in nasal biopsies after natural exposure and nasal challenge to allergen. (1) 20 nonatopic non-rhinitics were challenged with Der p 1 and recovery was measured by ELISA in the nasal wash, nasal mucus and induced sputum up to 30 minutes. Particulate charcoal (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0127477