Clinical characteristics and risk factors of pyogenic spondylitis caused by gram-negative bacteria

• Published in: PloS one 2015-05, Vol.10 (5), p.e0127126-e0127126
• Main Authors: Kang, Seung-Ji, Jang, Hee-Chang, Jung, Sook-In, Choe, Pyoeng Gyun, Park, Wan Beom, Kim, Chung-Jong, Song, Kyoung-Ho, Kim, Eu Suk, Kim, Hong Bin, Oh, Myoung-Don, Kim, Nam Joong, Park, Kyung-Hwa
• Format: Article
• Language: English
• Subjects: Aged; Antibiotics; Arthritis; Bacteria; Blood; Clinical outcomes; Cocci; Comparative analysis; Complications and side effects; Cross Infection - etiology; Cross Infection - microbiology; Cross Infection - pathology; E coli; Epidemiology; Etiology; Female; Genitourinary tract; Gram-negative bacteria; Gram-Negative Bacteria - pathogenicity; Gram-negative bacterial infections; Gram-Negative Bacterial Infections - etiology; Gram-Negative Bacterial Infections - microbiology; Gram-Negative Bacterial Infections - pathology; Gram-positive bacterial infections; Gram-positive cocci; Gram-Positive Cocci - pathogenicity; Hospitals; Humans; Infections; Infectious diseases; Internal medicine; Intra-abdominal infection; Intraabdominal Infections - etiology; Intraabdominal Infections - microbiology; Intraabdominal Infections - pathology; Laboratories; Male; Medical records; Medical research; Medical schools; Medicine; Middle Aged; Mortality; Pain; Patients; Physicians; Precision medicine; Pseudomonas aeruginosa; Quality; Retrospective Studies; Risk analysis; Risk Factors; Sepsis; Sepsis - etiology; Sepsis - microbiology; Sepsis - pathology; Spondylitis; Spondylitis - etiology; Spondylitis - microbiology; Spondylitis - pathology; Staphylococcus aureus; Studies; Tertiary Care Centers; Treatment Outcome; Trends
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0127126

There are limited data describing the clinical characteristics of pyogenic spondylitis caused by Gram-negative bacteria (GNB). The aim of this study was to investigate the predisposing factors and clinical characteristics of pyogenic spondylitis caused by GNB compared to Gram-positive cocci (GPC). We performed a retrospective review of medical records from patients with culture-confirmed pyogenic spondylitis at four tertiary teaching hospitals over an 8-year period. A total of 344 patients with culture-confirmed pyogenic spondylitis were evaluated. There were 62 patients (18.0%) with pyogenic spondylitis caused by GNB and the most common organism was Escherichia coli (n = 35, 10.2%), followed by Pseudomonas aeruginosa (n = 10, 2.9%). Pyogenic spondylitis caused by GNB was more frequently associated with the female gender (64.5 vs. 35.5%, P