The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru

The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis. To investigate the association of Mycobacterium t...

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Bibliographic Details
Published in:PloS one 2015-05, Vol.10 (5), p.e0126271-e0126271
Main Authors: Grandjean, Louis, Iwamoto, Tomotada, Lithgow, Anna, Gilman, Robert H, Arikawa, Kentaro, Nakanishi, Noriko, Martin, Laura, Castillo, Edith, Alarcon, Valentina, Coronel, Jorge, Solano, Walter, Aminian, Minoo, Guezala, Claudia, Rastogi, Nalin, Couvin, David, Sheen, Patricia, Zimic, Mirko, Moore, David A J
Format: Article
Language:English
Subjects:
Adult
Antibiotics
Bacteria
Bacteriology
Demographics
Deoxyribonucleic acid
Distribution
DNA
Drug resistance
Drug Resistance, Bacterial - genetics
Drugs
Epidemiology
Female
Founder effect
Genetic aspects
Genetic diversity
Genotype
Genotypes
Genotyping
Humans
Hygiene
Infectious diseases
Laboratories
Life Sciences
Male
Medication
Medicine
Microbial drug resistance
Microbiology and Parasitology
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Peru
Pharmaceutical sciences
Population
Prisoners
Santé publique et épidémiologie
Socioeconomics
Spoligotyping
Strains (organisms)
Supranationalism
Tuberculosis
Tuberculosis, Multidrug-Resistant - epidemiology
Tuberculosis, Multidrug-Resistant - microbiology
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Summary:The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis. To investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census. The Latin American Mediterranean (LAM) clade (OR 2.4, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0126271