Effects of blood transfusion on exercise capacity in thalassemia major patients

Anemia has an important role in exercise performance. However, the direct link between rapid changes of hemoglobin and exercise performance is still unknown.To find out more on this topic, we studied 18 beta-thalassemia major patients free of relevant cardiac dysfunction (age 33.5±7.2 years,males =...

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Published in:PloS one 2015-05, Vol.10 (5), p.e0127553-e0127553
Main Authors: Benedetto, Daniela, Rao, Carmelo Massimo, Cefalù, Claudia, Aguglia, Demetrio Oreste, Cattadori, Gaia, D'Ascola, Domenico Giuseppe, Benedetto, Frank Antonio, Agostoni, Piergiuseppe, Sciomer, Susanna
Format: Article
Language:English
Subjects:
Adult
Anaerobic Threshold
Anemia
Beta thalassemia
beta-Thalassemia - blood
beta-Thalassemia - physiopathology
beta-Thalassemia - therapy
Blood
Blood Transfusion
Blood transfusions
Carbon dioxide
Cardiology
Care and treatment
Chronic illnesses
Diabetes
Exercise
Female
Gases
Health aspects
Heart
Heart diseases
Heart failure
Hematology
Hemoglobin
Hemoglobins - metabolism
Humans
Iron
Male
Males
Mechanical ventilation
NMR
Nuclear magnetic resonance
Oxygen - blood
Patients
Physical fitness
Physiological aspects
Population
Thalassemia
Transfusion
Vanadium oxides
Ventilation
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creator Benedetto, Daniela
Rao, Carmelo Massimo
Cefalù, Claudia
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Cattadori, Gaia
D'Ascola, Domenico Giuseppe
Benedetto, Frank Antonio
Agostoni, Piergiuseppe
Sciomer, Susanna
description Anemia has an important role in exercise performance. However, the direct link between rapid changes of hemoglobin and exercise performance is still unknown.To find out more on this topic, we studied 18 beta-thalassemia major patients free of relevant cardiac dysfunction (age 33.5±7.2 years,males = 10). Patients performed a maximal cardiopulmolmonary exercise test (cycloergometer, personalized ramp protocol, breath-by-breath measurements of expired gases) before and the day after blood transfusion (500 cc of red cell concentrates). After blood transfusion, hemoglobin increased from 10.5±0.8 g/dL to 12.1±1.2 (p
doi_str_mv 10.1371/journal.pone.0127553
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Similarly, no relevant changes were observed in ventilation efficiency, as evaluated by the ventilation vs. carbon dioxide production relationship, or in O2 delivery to the periphery as analyzed by the VO2 vs. workload relationship. The relationship between hemoglobin and VO2 changes showed, for each g/dL of hemoglobin increase, a VO2 increase = 82.5 mL/min and 35 mL/min, at peak exercise and at anaerobic threshold, respectively. In beta-thalassemia major patients, an acute albeit partial anemia correction by blood transfusion determinates a relevant increase of exercise performance, observed both at peak exercise and at anaerobic threshold.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26010540</pmid><doi>10.1371/journal.pone.0127553</doi><oa>free_for_read</oa></addata></record>
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1932-6203
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subjects Adult
Anaerobic Threshold
Anemia
Beta thalassemia
beta-Thalassemia - blood
beta-Thalassemia - physiopathology
beta-Thalassemia - therapy
Blood
Blood Transfusion
Blood transfusions
Carbon dioxide
Cardiology
Care and treatment
Chronic illnesses
Diabetes
Exercise
Female
Gases
Health aspects
Heart
Heart diseases
Heart failure
Hematology
Hemoglobin
Hemoglobins - metabolism
Humans
Iron
Male
Males
Mechanical ventilation
NMR
Nuclear magnetic resonance
Oxygen - blood
Patients
Physical fitness
Physiological aspects
Population
Thalassemia
Transfusion
Vanadium oxides
Ventilation
title Effects of blood transfusion on exercise capacity in thalassemia major patients
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