Serological Evidence and Risk Factors for Swine Influenza Infections among Chinese Swine Workers in Guangdong Province

During July to September 2014, we performed a controlled, cross-sectional, seroepidemiologic study among 203 swine workers and 115 control subjects in Guangdong Province. Sera were tested using a hemagglutination inhibition assay against locally-isolated swine H3N2 and H1N1 viruses and commercially-...

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Bibliographic Details
Published in:PloS one 2015-05, Vol.10 (5), p.e0128479-e0128479
Main Authors: Ma, Mengmeng, Anderson, Benjamin D, Wang, Tao, Chen, Yingan, Zhang, Dingmei, Gray, Gregory C, Lu, Jiahai
Format: Article
Language:English
Subjects:
Adult
Agricultural laborers
Animals
Antibodies, Viral - immunology
Antigens
Antigens, Viral - immunology
China
Cross-Sectional Studies
Demographic aspects
Diseases
Enrollments
Epidemiology
Female
Health aspects
Health risks
Hemagglutination inhibition
Hemagglutination Inhibition Tests - methods
Hogs
Humans
Influenza
Influenza A Virus, H1N1 Subtype - immunology
Influenza A Virus, H3N2 Subtype - immunology
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - virology
Livestock
Male
Middle Aged
Pandemics
Respiratory diseases
Risk analysis
Risk Factors
Seroepidemiologic Studies
Studies
Swine
Swine - immunology
Swine - virology
Swine flu
Swine influenza
Vaccines
Viruses
Zoonoses
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Summary:During July to September 2014, we performed a controlled, cross-sectional, seroepidemiologic study among 203 swine workers and 115 control subjects in Guangdong Province. Sera were tested using a hemagglutination inhibition assay against locally-isolated swine H3N2 and H1N1 viruses and commercially-obtained human influenza viral antigens. We found swine workers had a greater prevalence and odds of seropositivity against the swine H3N2 virus (17.3% vs. 7.0%; adjusted OR, 3.4; 95% CI, 1.1 -10.7). Younger age, self-report of a respiratory illness during the last 12 months, and seropositivity against seasonal H3N2 virus were identified as significant risk factors for seropositivity against swine H3N2 virus. As swine workers in China may be exposed to novel influenza viruses, it seems prudent for China to conduct special surveillance for such viruses among them. It also seems wise to offer such workers seasonal influenza vaccines with a goal to reduce cross-species influenza virus transmission.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0128479