Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study

• Published in: PloS one 2015-05, Vol.10 (5), p.e0128671-e0128671
• Main Authors: Chen, Li-Wei, Chien, Chih-Yi, Yang, Kai-Jie, Kuo, Sheng-Fong, Chen, Chih-Hung, Chien, Rong-Nan
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Analysis; Antibodies; Antibodies, Bacterial - blood; Biochemistry; Cardiovascular disease; Care and treatment; Case-Control Studies; Communities; Cytokines; Demographics; Development and progression; Female; Genetic aspects; Health aspects; Helicobacter infections; Helicobacter Infections - blood; Helicobacter Infections - epidemiology; Helicobacter Infections - physiopathology; Helicobacter pylori; Humans; Hypertension; Hypertension - blood; Hypertension - epidemiology; Hypertension - microbiology; Hypertension - physiopathology; Incidence; Infections; Inflammation; Insulin; Insulin Resistance; Leptin; Leptin - blood; Liver; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Metabolic Syndrome - microbiology; Metabolic Syndrome - physiopathology; Middle Aged; Multivariate analysis; Patient outcomes; Risk factors; Studies; Sugar; Surveys; Taiwan; Tumor necrosis factor-TNF; Tumor necrosis factor-α
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0128671

This study aimed to analyze the influence of H. pylori infection on insulin resistance and metabolic syndrome (MS) by multivariate analysis of a community-based cohort study. From January 2013 to February 2014,811 subjects were enrolled in a community-based cohort study from the northeastern region of Taiwan. All subjects received a demographic survey and blood tests, including an H. pylori antibody test, liver biochemistry tests, lipid profiles, sugar/insulin levels for Homeostatic model assessment (HOMA-IR index), and measurements of adipokines and inflammatory cytokines. A total of 264 men and 547 women were included in this study. The mean age was 59.2 ± 12.7 years. Subjects seropositive for H. pylori antibodies exhibited higher rates of hypertension, an increased incidence of a HOMA-IR index > 2.5 and a higher level of tumor necrosis factor-α than those without H. pylori antibodies. We found a significant difference in the presence of H. pylori antibodies between subjects with MS and those without MS (76.7% vs. 53.7%, p = 0.007) among subjects < 50 y/o. A HOMA-IR index >2.5, H. pylori antibody presence and leptin were predictors for MS in subjects < 50 y/o. The estimated odds ratio of MS for a subject with H. pylori antibodies was 3.717 (95% CI = 1.086-12.719) times that of a subject without H. pylori antibodies. In addition, no difference in H. pylori antibody status was detected for MS prediction in subjects that were ≧ 50 y/o (p = 0.861). In conclusion, subjects with H. pylori antibodies had a higher incidence of a HOMA-IR >2.5 than those without H pylori antibodies. For subjects aged < 50 y/o, the H. pylori antibody was a predictor for MS.