Acute chagas disease: new global challenges for an old neglected disease

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although over 100 years have passed since the discovery of Chagas disease, it still presents an increasing problem for global public health. A plethora of information concerning the chronic phase of human Chagas disease,...

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Published in:PLoS neglected tropical diseases 2014-07, Vol.8 (7), p.e3010-e3010
Main Authors: Andrade, Daniela V, Gollob, Kenneth J, Dutra, Walderez O
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Chagas Disease - epidemiology
Chagas Disease - immunology
Chagas Disease - pathology
Chagas' disease
Developing countries
Development and progression
Global Health
Humans
Infection control
LDCs
Medical research
Medicine and Health Sciences
Medicine, Experimental
Neglected Diseases - epidemiology
Neglected Diseases - immunology
Neglected Diseases - pathology
Parasitic diseases
Patients
Pharmaceutical industry
R&D
Recurrence
Research & development
Review
Topography, Medical
Trypanosoma cruzi
Trypanosoma cruzi - immunology
Trypanosoma cruzi - isolation & purification
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description Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although over 100 years have passed since the discovery of Chagas disease, it still presents an increasing problem for global public health. A plethora of information concerning the chronic phase of human Chagas disease, particularly the severe cardiac form, is available in the literature. However, information concerning events during the acute phase of the disease is scarce. In this review, we will discuss (1) the current status of acute Chagas disease cases globally, (2) the immunological findings related to the acute phase and their possible influence in disease outcome, and (3) reactivation of Chagas disease in immunocompromised individuals, a key point for transplantation and HIV infection management.
doi_str_mv 10.1371/journal.pntd.0003010
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identifier ISSN: 1935-2735
ispartof PLoS neglected tropical diseases, 2014-07, Vol.8 (7), p.e3010-e3010
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subjects Biology and Life Sciences
Chagas Disease - epidemiology
Chagas Disease - immunology
Chagas Disease - pathology
Chagas' disease
Developing countries
Development and progression
Global Health
Humans
Infection control
LDCs
Medical research
Medicine and Health Sciences
Medicine, Experimental
Neglected Diseases - epidemiology
Neglected Diseases - immunology
Neglected Diseases - pathology
Parasitic diseases
Patients
Pharmaceutical industry
R&D
Recurrence
Research & development
Review
Topography, Medical
Trypanosoma cruzi
Trypanosoma cruzi - immunology
Trypanosoma cruzi - isolation & purification
title Acute chagas disease: new global challenges for an old neglected disease
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