Plasmepsin V, a secret weapon against malaria

  Both parasites spend a large portion of their life cycle living and replicating within human red blood cells (erythrocytes). Standard techniques for gene disruption involve creating a genetic construct containing a gene cassette that confers resistance to a particular drug and inserts itself into...

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Bibliographic Details
Published in:PLoS biology 2014-07, Vol.12 (7), p.e1001898-e1001898
Main Author: Sedwick, Caitlin
Format: Article
Language:English
Subjects:
Aspartic Acid Endopeptidases - antagonists & inhibitors
Aspartic Acid Proteases - antagonists & inhibitors
Bacterial proteins
Biology and Life Sciences
Endoplasmic reticulum
Enzymes
Erythrocytes
Health aspects
Host-parasite relationships
Humans
Malaria
Microbiological research
Oligopeptides - pharmacology
Parasites
Prevention
Protein research
Proteins
Protozoan Proteins - antagonists & inhibitors
Protozoan Proteins - metabolism
Studies
Sulfonamides - pharmacology
Citations: Items that cite this one
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Description
Summary:  Both parasites spend a large portion of their life cycle living and replicating within human red blood cells (erythrocytes). Standard techniques for gene disruption involve creating a genetic construct containing a gene cassette that confers resistance to a particular drug and inserts itself into the target gene, disrupting the target's coding sequence.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.1001898