Development of spinal cord neurons in delicate balance

  [...]the chemical signals that drive differentiation of NMPs were unknown. [...]previous studies have shown that, during development, cells in the posterior of the embryo are exposed to Fgf and another secreted signaling protein called wingless (Wnt). [...]Gouti et al. reasoned that Fgf and Wnt ma...

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Bibliographic Details
Published in:PLoS biology 2014-08, Vol.12 (8), p.e1001938-e1001938
Main Author: Sedwick, Caitlin
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Cell Differentiation
Embryos
Equilibrium (Physiology)
Gene expression
Humans
Mesoderm - cytology
Neural circuitry
Neural Stem Cells - cytology
Neurological research
Neurons
Neurons - cytology
Physiological aspects
Spinal cord
Spinal Cord - cytology
Spinal Cord - embryology
Stem cells
Studies
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Summary:  [...]the chemical signals that drive differentiation of NMPs were unknown. [...]previous studies have shown that, during development, cells in the posterior of the embryo are exposed to Fgf and another secreted signaling protein called wingless (Wnt). [...]Gouti et al. reasoned that Fgf and Wnt may cooperate to guide development of NMPs, and could also be able to induce mESCs to differentiate into NMPs in vitro.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.1001938