Loading…
The wide world of ribosomally encoded bacterial peptides
Bacterial peptides produced by both gram-positive and gram-negative bacteria include antimicrobial peptides such as Nisin and Microcin B17, known host virulence factors such as the Streptolysin S-like cytolysins, and the peptide cytolysin from E. faecalis. Streptolysin S has been identified as a m...
Saved in:
Published in: | PLoS pathogens 2014-07, Vol.10 (7), p.e1004221-e1004221 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: |
Bacterial peptides produced by both gram-positive and gram-negative bacteria include antimicrobial peptides such as Nisin and Microcin B17, known host virulence factors such as the Streptolysin S-like cytolysins, and the peptide cytolysin from E. faecalis. Streptolysin S has been identified as a major contributing factor in successful translocation of Streptococcus pyogenes across the epithelial barrier through a mechanism involving the disruption of intracellular junctions via cleavage of occludin and E-cadherin [13].\n Bacteriocin-like peptides are highly attractive candidates for genome mining, as these natural products are genetically encoded with nearby genes encoding their corresponding modifying enzymes. |
---|---|
ISSN: | 1553-7374 1553-7366 1553-7374 |
DOI: | 10.1371/journal.ppat.1004221 |