Microbial programming of systemic innate immunity and resistance to infection

  Functionally, circulating neutrophils in germ-free mice have defects in extravasation from the bloodstream into target tissues in response to microbial signals [7] and also in killing of bacterial pathogens [8]. [...]signals from the microbiota have a systemic effect on neutrophils promoting their...

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Bibliographic Details
Published in:PLoS pathogens 2014-12, Vol.10 (12), p.e1004506-e1004506
Main Author: Clarke, Thomas B
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial infections
Biology and Life Sciences
Cytokines
Defects
Defense
Homeostasis
Host-parasite relationships
Humans
Immune response
Immune system
Immunity, Innate
Immunological research
Infections
Infections - immunology
Influence
Interferon
Medicine and Health Sciences
Pearls
Rodents
Tuberculosis
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Summary:  Functionally, circulating neutrophils in germ-free mice have defects in extravasation from the bloodstream into target tissues in response to microbial signals [7] and also in killing of bacterial pathogens [8]. [...]signals from the microbiota have a systemic effect on neutrophils promoting their production and antimicrobial capacity. Additionally, it is known that patients with concurrent intestinal helminth and TB infection have reduced natural killer cell numbers in comparison to those with TB alone [25]. [...]more information is required to understand the beneficial and detrimental effects different microbial groups can have on innate immunity.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004506